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TRAF5 Antibody

  • 货号：
    CSB-PA024153GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O00463
  • 基因名：
  • 别名：
    MGC:39780 antibody; RING finger protein 84 antibody; RNF 84 antibody; RNF84 antibody; TNF receptor associated factor 5 antibody; TNF receptor-associated factor 5 antibody; TRAF 5 antibody; Traf5 antibody; TRAF5_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human TRAF5
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.
  • 基因功能参考文献：
    1. High TRAF5 expression is associated with colorectal cancer. PMID: 29328486
    2. These findings indicate that miR-26b might influence TRAF5-MAPK signaling pathways to facilitate the malignant progression of melanoma cells. PMID: 26872428
    3. findings reveal a direct link between TRAF5-mediated ubiquitination and RORgammat protein regulation PMID: 26453305
    4. This study provides evidence that TRAF5 and TRAF3IP2 genes are involved in the development of Behcet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome. PMID: 24416204
    5. Data indicate that TNF receptor-associated factor 5 (TRAF5) gene is involved in the development of acute anterior uveitis (AAU) and pediatric uveitis. PMID: 24020968
    6. TRAF3 and TRAF5 are overexpressed in inflammatory bowel disease PMID: 23329887
    7. Numbl interacted with tumor necrosis factor receptor-associated factor 5, which signals upstream and is required for the activation of NF-kappaB, and committed it to proteasomal degradation by promoting K48-linked polyubiquitination of TRAF5 PMID: 22593207
    8. Resutls indicate that TRAF5 may be a key molecule in the innate response against viral infection. PMID: 20161788
    9. TRAF5 has a role in TNF-alpha induced IKK phosphorylation of NF-kappaB p65 PMID: 12842894
    10. These findings provide evidence for the association of an SNP upstream of a strong candidate RA susceptibility gene, TRAF5. PMID: 17277003

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytosol.
  • 蛋白家族：
    TNF receptor-associated factor family, A subfamily
  • 组织特异性：
    Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood.
  • 数据库链接：

    HGNC: 12035

    OMIM: 602356

    KEGG: hsa:7188

    STRING: 9606.ENSP00000261464

    UniGene: Hs.523930