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  4. TRAK2 Antibody

TRAK2 Antibody

  • 货号：
    CSB-PA050107
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    O60296
  • 基因名：
    TRAK2
  • 别名：
    ALS2CR 3 antibody; ALS2CR3 antibody; Amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 3 antibody; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein antibody; CALS C antibody; GRIF 1 antibody; GRIF1 antibody; KIAA0549 antibody; OIP98 antibody; Trafficking kinesin-binding protein 2 antibody; Trafficking protein kinesin binding 2 antibody; Trak2 antibody; TRAK2_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human GRIF-1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR.
  • 基因功能参考文献：
    1. This study showed that the TRAK2 was more prevalent in dendrites of hippocampal neurons. In cortical neurons, TRAK2 was equally distributed between axons and dendrites. PMID: 25653102
    2. The results of this study established a key role for mammalian TRAK2 proteins in axonal and dendritic targeting of mitochondria. PMID: 23395375
    3. identification, molecular cloning and characterization PMID: 12034717
    4. GRIF-1 and OIP106 have roles in protein and/or organelle transport in excitable cells in a manner analogous to glutamate receptor-interacting-protein 1 PMID: 15644324
    5. analysis of the GRIF-1 binding domain of the kinesin, KIF5C, which substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes PMID: 16835241
    6. Binds to Kir2.1 and facilitates trafficking of this channel to the cell surface. PMID: 16895905

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  • 亚细胞定位：
    Cytoplasm. Early endosome. Mitochondrion.
  • 组织特异性：
    Widely expressed, with highest expression in heart.
  • 数据库链接：

    HGNC: 13206

    OMIM: 607334

    KEGG: hsa:66008

    STRING: 9606.ENSP00000328875

    UniGene: Hs.152774