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TRAPPC4 Antibody

  • 中文名称：
    TRAPPC4兔多克隆抗体
  • 货号：
    CSB-PA024230GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y296
  • 基因名：
    TRAPPC4
  • 别名：
    TRAPPC4 antibody; SBDN antibody; CGI-104 antibody; HSPC172 antibody; PTD009 antibody; Trafficking protein particle complex subunit 4 antibody; Hematopoietic stem/progenitor cell protein 172 antibody; Synbindin antibody; TRS23 homolog antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human TRAPPC4
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase. Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy. May play a role in dendrite postsynaptic membrane trafficking.
  • 基因功能参考文献：
    1. Overexpression of TRAPPC4 increased colorectal carcinogenesis. PMID: 23625650
    2. Synbindin contributes to malignant phenotypes of GC by activating ERK on the Golgi, and synbindin is a potential biomarker and therapeutic target for GC. PMID: 24104608
    3. Data demonstrate that TRAPPC4 may regulate cell proliferation and apoptosis in CRC by interaction with ERK2 and phosphorylating ERK1/2 as well as modulating the subcellular location of pERK1/2 to activate the relevant signaling pathway. PMID: 21826244
    4. The three-dimensional structure of human synbindin, which contains a longin domain and an atypical PDZ domain is presented. PMID: 18466758
  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane. Golgi apparatus membrane. Endoplasmic reticulum. Vesicle.
  • 蛋白家族：
    TRAPP small subunits family, TRAPPC4 subfamily
  • 数据库链接：

    HGNC: 19943

    OMIM: 610971

    KEGG: hsa:51399

    STRING: 9606.ENSP00000436005

    UniGene: Hs.132760