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TRDMT1 Antibody

  • 货号：
    CSB-PA199904
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA199904(TRDMT1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    O14717
  • 基因名：
    TRDMT1
  • 别名：
    dDNMT antibody; DmMT 2 antibody; DmMT2 antibody; DNA (cytosine 5 ) methyltransferase 2 antibody; DNA (cytosine 5) methyltransferase like protein 2 antibody; DNA (cytosine-5)-methyltransferase-like protein 2 antibody; DNA 5 cytosine methyltransferase antibody; DNA methyltransferase 2 antibody; DNA methyltransferase homolog HsaIIP antibody; DNA MTase homolog HsaIIP antibody; Dnmt 2 antibody; Dnmt2 antibody; M.HsaIIP antibody; MHsaIIP antibody; nmt 2 antibody; nmt2 antibody; OTTHUMP00000045198 antibody; PuMet antibody; RNMT 1 antibody; RNMT1 antibody; TRDMT 1 antibody; TRDMT_HUMAN antibody; TRDMT1 antibody; tRNA (cytosine 5 ) methyltransferase antibody; tRNA (cytosine(38)-C(5))-methyltransferase antibody; tRNA aspartic acid methyltransferase 1 antibody; tRNA aspartic acid methyltransferase 1 variant 1 antibody; tRNA aspartic acid methyltransferase 1 variant 2 antibody; tRNA aspartic acid methyltransferase 1 variant 3 antibody; tRNA aspartic acid methyltransferase 1 variant 4 antibody; tRNA aspartic acid methyltransferase 1 variant 5 antibody; tRNA aspartic acid methyltransferase 1 variant 8 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human TRDMT1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).
  • 基因功能参考文献：
    1. Data suggest that, upon HIV-1 infection, DNMT2 is re-localized from the nucleus to cytoplasmic stress granules where DNMT2 methylates HIV-1 messenger RNA; this methylation increases the stability of the HIV-1 RNA genome and up-regulates virus replication; thus, DNMT2 appears to facilitate HIV-1 infection. PMID: 28476776
    2. The strong effect of some of the somatic cancer mutations on DNMT2 activity suggests that these mutations have a functional role in tumorigenesis. PMID: 25747896
    3. Mapped is the tRNA binding site of DNMT2 by systematically mutating surface-exposed lysine and arginine residues to alanine and studying the tRNA methylation activity and binding of the corresponding variants. PMID: 22591353
    4. the role of Dnmt2 in stress granules could represent a primitive cellular defense mechanism against viral infection. PMID: 20864816
    5. identification of residual DNA-(cytosine-C5) methyltransferase activity PMID: 12794065
    6. cDNA microarray analysis identified several genes involved in DNA methylation, such as DNMT2 and DNMT3a that were more highly expressed in LNCaP-r (an androgen sensitive prostate cancer cell line). PMID: 16173030
    7. genetic and biochemical approach revealed that DNMT2 did not methylate DNA but instead methylated aspartic acid transfer RNA (tRNA(Asp)) and that DNMT2 specifically methylated cytosine 38 in the anticodon loop PMID: 16424344
    8. An association study of 45 folate-related genes in spina bifida: Involvement of tRNA aspartic acid methyltransferase 1 (TRDMT1) PMID: 19161160

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Class I-like SAM-binding methyltransferase superfamily, C5-methyltransferase family
  • 组织特异性：
    Ubiquitous. Higher expression in testis, ovary and thymus and at much lower levels in spleen, prostate, colon, small intestine, and peripheral blood leukocytes.
  • 数据库链接：

    HGNC: 2977

    OMIM: 602478

    KEGG: hsa:1787

    STRING: 9606.ENSP00000367030

    UniGene: Hs.351665