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TRDN Antibody

  • 货号：
    CSB-PA024398LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of U251 cells with CSB-PA024398LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TRDN Polyclonal antibody
  • Uniprot No.：
    Q13061
  • 基因名：
    TRDN
  • 别名：
    dJ166D18.1 antibody; DKFZp779I2253 antibody; MGC88285 antibody; OTTHUMP00000040354 antibody; TDN antibody; TRDN antibody; TRDN_HUMAN antibody; Triadin antibody; TRISK 51 antibody; TRISK antibody; TRISK51 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Triadin protein (75-161AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TRDN Antibody (CSB-PA024398LA01HU)，的标记方式是Non-conjugated。对于TRDN Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA024398LB01HU TRDN Antibody, HRP conjugated ELISA
    FITC CSB-PA024398LC01HU TRDN Antibody, FITC conjugated
    Biotin CSB-PA024398LD01HU TRDN Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
  • 基因功能参考文献：
    1. The lncRNA TRDN-AS regulates the balance between cardiac and skeletal isoforms of triadin. PMID: 29126880
    2. CLIMP-63 (also known as CKAP4), is the partner of triadin, is responsible for this association of triads and microtubules. PMID: 27562070
    3. A compound heterozygous mutation in the triadin gene resulted in a particularly arrhythmogenic phenotype with with cardiac arrest in two siblings. PMID: 26768964
    4. We describe a new family with cathecholaminergic polymorphic ventricular tachycardia (CPVT) linked to the Triadin gene. PMID: 26200674
    5. Common variants in TRDN and CALM1 are associated with increased risk of sudden cardiac death in patients with chronic heart failure. PMID: 26196381
    6. TRDN is a novel underlying genetic basis for recessively inherited Long-QT syndrome. PMID: 25922419
    7. Data show that triadin (TRDN) is a new gene responsible for an autosomal recessive form of ctecholaminergic polymorphic ventricular tachycardia (CPVT). PMID: 22422768
    8. The researchers found evidence that TRDN may be a susceptibility or marker gene for IgA nephropathy PMID: 19890582
    9. gene organization and cloning of the major isoform PMID: 12659871
    10. Histidine-rich Ca-binding protein may play a key role in the regulation of SR Ca cycling through its direct interactions with SERCA2 and triadin, mediating a fine cross talk between SR Ca uptake and release in the heart. PMID: 17526652
    11. proteasome inhibition led to an accumulation of two new modified forms of triadin-1 that were seen with triadin-1 only when it is not glycosylated on Asn(75). PMID: 18025088

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  • 相关疾病：
    Ventricular tachycardia, catecholaminergic polymorphic, 5, with or without muscle weakness (CPVT5)
  • 亚细胞定位：
    Cell membrane. Sarcoplasmic reticulum membrane; Single-pass type II membrane protein.
  • 数据库链接：

    HGNC: 12261

    OMIM: 603283

    KEGG: hsa:10345

    STRING: 9606.ENSP00000381240

    UniGene: Hs.144744