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TRIM27 Antibody

  • 货号：
    CSB-PA133989
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA133989(TRIM27 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA133989(TRIM27 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P14373
  • 基因名：
    TRIM27
  • 别名：
    AW538890 antibody; DAAP-182E11.3 antibody; MGC189472 antibody; OTTHUMP00000029314 antibody; Ret finger protein antibody; RFP antibody; RFP transforming protein antibody; Rfp1 antibody; RING finger protein 76 antibody; RNF76 antibody; TRI27_HUMAN antibody; TRIM 27 antibody; Trim27 antibody; Tripartite motif containing 27 antibody; Tripartite motif containing protein 27 antibody; Tripartite motif protein TRIM27 antibody; Tripartite motif-containing protein 27 antibody; Zinc finger protein RFP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human TRIM27
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly. Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.
  • 基因功能参考文献：
    1. Results showed that TRIM27 was upregulated in colorectal cancer (CRC) tissues, and significantly associated with tumor invasion, metastasis and prognosis. Following TRIM27 inhibition and overexpression in CRC cells, it was found that TRIM27 promoted cell proliferation, possibly via the inhibition of apoptosis and cell cycle regulation. These results suggested that TRIM27 is an oncogenic protein in the progression of CRC. PMID: 29767249
    2. Results demonstrated that TRIM27 restricts the intracellular survival of mycobacteria, suggesting that it is a potential host restriction factor for Mycobacterium tuberculosis by enhancing host immune-inflammatory responses mediated by JNK/p38 pathways as well as cell apoptosis. PMID: 27698396
    3. RFP scores were higher both in serous and grade 3 endometrioid carcinoma (p > 0.05), and significantly lower in grade 1 endometrioid carcinoma (p < 0.05). PMID: 28155970
    4. Studied the expression of TRIM27 in normal ovarian and fallopian tube epithelial cells and in ovarian serous carcinoma cells; correlated TRIM27 expression with clinical and pathological parameters. PMID: 26568293
    5. Study found that compared to healthy individuals, Trim27 was significantly upregulated in patients with Parkinson's disease PMID: 25223908
    6. The neoplasm leading cell specific expression of integrin beta1 was posttranscriptionally regulated by the TRIM27/MRTF-B complex in response to the loss of intercellular adhesion. PMID: 24794433
    7. s observed rapid, ICP0-dependent loss of TRIM27 during HSV-1 infection. PMID: 25320289
    8. RFP-knockdown ovarian cancer cells exhibited lower carboplatin resistance than control cells. These findings suggest that RFP could be a predictive marker for chemoresistance in ovarian cancer patients. PMID: 23342271
    9. These findings provide a cellular and molecular function for MAGE-L2-TRIM27 in retrograde transport, including an unappreciated role of K63-linked ubiquitination and identification of an activating signal of the WASH regulatory complex. PMID: 23452853
    10. Data conclude that TRIM27 negatively regulates NOD2-mediated signaling by degradation of NOD2 and suggest that TRIM27 could be a new target for therapeutic intervention in NOD2-associated diseases. PMID: 22829933
    11. TRIM27 expression is a modifier of cancer incidence and progression and is a potential target for intervention. PMID: 22556269
    12. These findings provide a unique mechanism for regulating class II PI3Ks, and identify TRIM27 as a previously undescribed negative regulator of CD4 T cells. PMID: 22128329
    13. role in inducing apoptosis via its RING finger-B box-coiled-coil motif PMID: 12807881
    14. the amino-terminal and carboxyl-terminal regions of Mi-2 beta have distinct transcriptional activities and bind to BRG1 and the RET finger protein, forming a multiprotein supercomplex involved in transcriptional regulation. PMID: 14530259
    15. RFP selectively ablates Rb function. PMID: 15837424
    16. Mi-2beta and RFP, known to be involved in transcriptional repression in the nucleus, co-localize with MCRS1 in the nucleolus and appear to activate the rRNA transcription. PMID: 16186106
    17. RFP negatively regulates signaling involved in the antiviral response and inflammation by targeting the IKKs. PMID: 16393995
    18. Our study is the first in the literature to show expression of RET finger protein in patients with breast carcinoma PMID: 19232840

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  • 相关疾病：
    A chromosomal aberration involving TRIM27/RFP is found in papillary thyroid carcinomas (PTCs). Translocation t(6;10)(p21.3;q11.2) with RET. The translocation generates TRIM27/RET and delta TRIM27/RET oncogenes.
  • 亚细胞定位：
    Nucleus. Cytoplasm. Nucleus, PML body. Early endosome.
  • 蛋白家族：
    TRIM/RBCC family
  • 组织特异性：
    Expressed in testis namely within the seminiferous tubules.
  • 数据库链接：

    HGNC: 9975

    OMIM: 602165

    KEGG: hsa:5987

    STRING: 9606.ENSP00000366404

    UniGene: Hs.440382