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TRIM3 Antibody

  • 货号：
    CSB-PA006667
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COLO cells using TRIM3 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O75382
  • 基因名：
    TRIM3
  • 别名：
    BERP antibody; Brain expressed ring finger antibody; Brain-expressed RING finger protein antibody; FLJ16135 antibody; HAC1 antibody; RING finger protein 22 antibody; RING finger protein 97 antibody; RNF22 antibody; RNF97 antibody; Trim3 antibody; TRIM3_HUMAN antibody; Tripartite motif containing 3 antibody; Tripartite motif protein TRIM3 antibody; Tripartite motif-containing protein 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human TRIM3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Positively regulates motility of microtubule-dependent motor protein KIF21B.
  • 基因功能参考文献：
    1. TRIM3 plays a tumor-suppressing role in the regulation of liver cancer development by reducing cell proliferation through cell cycle arrest at the G0/G1 phase. PMID: 28950898
    2. The results of quantitative real-time RT-PCR and western blotting showed that the TRIM3 expression was very low in five cervical cancer cell lines. The TRIM3 overexpression weakened cell viability, and promote apoptosis of C-33A and SiHa cells in vitro, and inhibit tumor growth in vivo, which suggested that TRIM3 could reduce proliferation of cervical cancer cells. PMID: 29524410
    3. TRIM3 exerted an anti-proliferation role in rheumatoid arthritis fibroblast-like synoviocytes via p38 signaling pathway. PMID: 28259936
    4. results support a novel role for Brat/TRIM3 in maintaining stem cell equilibrium and suppressing tumor growth by regulating NICD nuclear transport PMID: 26893479
    5. TRIM3 functions as a tumour suppressor in CRC progression. This tumour-suppressive function is exerted partially through regulation of p53 protein. PMID: 26691157
    6. Studies indicate most-studied TRIpartite Motif (TRIM)-NHL proteins TRIM2, TRIM3, TRIM32 and TRIM71, and their mutations have been linked to diseases. PMID: 26514622
    7. TRIM3 may play a significant role in hepatocellular carcinoma progression.TRIM3 is downregulated in hepatocellular carcinoma at both the mRNA and protein levels and that low TRIM3 expression is correlated with an unfavorable prognosis. PMID: 24994609
    8. TRIM3 acts as a tumor suppressor in GBM by restoring asymmetric cell division. PMID: 24947043
    9. Data indicate TRIM3 and p21 interact in cells. PMID: 23318451
    10. TRIM63 is a candidate for genes mediating the glucocorticoid-induced promotion of osteoblastic differentiation. PMID: 20173306
    11. brain-expressed RING finger protein (BERP) is a gene whose expression is up-regulated in a p53-dependent manner PMID: 20543135
    12. the endosome-associated protein hrs is a subunit of a protein complex containing actinin-4, BERP, and myosin V that is necessary for efficient TfR recycling but not for EGFR degradation PMID: 15772161
    13. Loss of heterozygosity of chromosome segment 11p15.5 in malignant gliomas suggests TRIM3 as a candidate brain tumor suppressor gene. PMID: 19250537

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  • 亚细胞定位：
    Cytoplasm. Early endosome. Golgi apparatus, trans-Golgi network. Cell projection, dendrite.
  • 蛋白家族：
    TRIM/RBCC family
  • 组织特异性：
    Expressed in brain, heart, uterus and testis.
  • 数据库链接：

    HGNC: 10064

    OMIM: 605493

    KEGG: hsa:10612

    STRING: 9606.ENSP00000340797

    UniGene: Hs.591992