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TRIM37 Antibody

  • 货号：
    CSB-PA024474GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O94972
  • 基因名：
  • 别名：
    E3 ubiquitin protein ligase TRIM37 antibody; E3 ubiquitin-protein ligase TRIM37 antibody; KIAA0898 antibody; MUL antibody; MUL protein antibody; Mulibrey nanism gene antibody; Mulibrey nanism protein antibody; POB 1 antibody; POB1 antibody; RING B box coiled coil protein antibody; TEF 3 antibody; TEF3 antibody; TRI37_HUMAN antibody; TRIM 37 antibody; Trim37 antibody; Tripartite motif containing 37 antibody; Tripartite motif containing 37 protein antibody; Tripartite motif containing protein 37 antibody; Tripartite motif-containing protein 37 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human TRIM37
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase required to prevent centriole reduplication. Probably acts by ubiquitinating positive regulators of centriole reduplication. Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes. Has anti-HIV activity.
  • 基因功能参考文献：
    1. TRIM37 functions as an oncogene in the development and progression of glioma. PMID: 29324313
    2. TRIM37 mutation is associated with mulibrey nanism. PMID: 28815877
    3. TRIM37-mediated ubiquitylation stabilizes PEX5 and promotes peroxisomal matrix protein import, suggesting that mulibrey nanism is a new peroxisomal biogenesis disorder. PMID: 28724525
    4. TRIM37 was overexpressed in human CRC tissues. High TRIM37 expression resulted in increased CRC proliferation, migration and invasion. Mechanistically, it was confirmed that TRIM37 enhanced invasion and metastasis of CRC via the epithelialmesenchymal transition pathway. PMID: 28098873
    5. knockdown of TRIM37 markedly downregulated the expression of beta-catenin, cyclin D1, and c-Myc in CRC cells. These results suggest that knockdown of TRIM37 inhibits proliferation and tumorigenesis by the inactivation of Wnt/beta-catenin signaling in CRC cells. PMID: 28081740
    6. The oncogenic roles of TRIM37 in pancreatic cancer. PMID: 26395261
    7. These finding may provide insight into the understanding of TRIM37 as a novel critical factor of HCC and a candidate target for HCC treatment. PMID: 26208456
    8. results reveal TRIM37 as an oncogenic H2A ubiquitin ligase that is overexpressed in a subset of breast cancers and promotes transformation by facilitating silencing of tumour suppressors and other genes. PMID: 25470042
    9. Our report underlines the necessity of early clinical diagnosis of Mulibrey nanism. Careful cardiologic examination is required to detect constrictive pericarditis, which is a major factor of mortality in these patients PMID: 23385855
    10. In this study, s demonstrate that human Trim 37 possesses anti-HIV-1 activity. PMID: 24317724
    11. The TRIM37 gene encodes a peroxisomal RING-B-box-coiled-coil protein: classification of mulibrey nanism as a new peroxisomal disorder PMID: 11938494
    12. novel splice variants observed in lymphoblastoid cells and muscle tissue of normal subjects and mulibrey nanism patients PMID: 12754710
    13. The TRIM37 acts as a TRIM domain-dependent E3 ubiquitin ligase and imply defective ubiquitin-dependent degradation of an as-yet-unidentified target protein in the pathogenesis of mulibrey nanism. PMID: 15885686
    14. Functional link of TRIM37 to the ubiquitin-proteosome pathway may provide novel clues to the development of metabolic syndrome. PMID: 16306379
    15. TRIM37 expression is regulated by several mechanisms: through nonsense surveillance of non-functional transcripts, as well as through 3'UTR regulatory sequences and/or naturally occurring antisense RNAs especially in testis. PMID: 16310976
    16. Novel mutations in the tumor necrosis factor receptor associated factor (TRAF) domain alter the subcellular localization of TRIM37, and are associated with Wilm's tumor in a patient with mulibrey nanism. PMID: 17100991
    17. Mutation screening of the TRIM37 gene revealed that the proband had a homozygous two base pair deletion, c.1894_1895delGA, resulting in a frame-shift and a premature termination codon. PMID: 17551331
    18. inherited biallelic inactivation of TRIM37 (Mulibrey nanism) predisposes to both mesenchymal and epithelial ovarian tumors and dysregulation of TRIM37 may also be involved in the pathogenesis of sporadic fibrothecomas. PMID: 19329943

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  • 相关疾病：
    Mulibrey nanism (MUL)
  • 亚细胞定位：
    Cytoplasm, perinuclear region. Peroxisome.
  • 蛋白家族：
    TRIM/RBCC family
  • 组织特异性：
    Ubiquitous. Highly expressed in testis, while it is weakly expressed in other tissues.
  • 数据库链接：

    HGNC: 7523

    OMIM: 253250

    KEGG: hsa:4591

    STRING: 9606.ENSP00000262294

    UniGene: Hs.579079