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TRIM71 Antibody

  • 货号：
    CSB-PA652403LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA652403LA01HU diluted at 1:600 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA652403LA01HU diluted at 1:600 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TRIM71 Polyclonal antibody
  • Uniprot No.：
    Q2Q1W2
  • 基因名：
    TRIM71
  • 别名：
    2610206G21Rik antibody; Abnormal cell LINeage LIN 41 antibody; AL022943 antibody; E3 ubiquitin-protein ligase TRIM71 antibody; Gm1127 antibody; Homolog of C. elegans Lin 41 antibody; LIN 41 antibody; LIN41 antibody; LIN41_HUMAN antibody; mlin 41 antibody; Protein lin 41 homolog antibody; Protein lin-41 homolog antibody; RGD1566388 antibody; Ripply2 antibody; TRIM 71 antibody; TRIM71 antibody; Tripartite motif containing 71 antibody; Tripartite motif-containing protein 71 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase TRIM71 protein (125-209AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TRIM71 Antibody (CSB-PA652403LA01HU)，的标记方式是Non-conjugated。对于TRIM71 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA652403LB01HU TRIM71 Antibody, HRP conjugated ELISA
    FITC CSB-PA652403LC01HU TRIM71 Antibody, FITC conjugated
    Biotin CSB-PA652403LD01HU TRIM71 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1. Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression.
  • 基因功能参考文献：
    1. TRIM71 acts through post-transcriptional repression of Lin28B and subsequent modulation of let-7-HMGA2 signaling during tumorigenesis to potentially function as a tumor suppressor. PMID: 27821801
    2. Studies indicate most-studied TRIpartite Motif (TRIM)-NHL proteins TRIM2, TRIM3, TRIM32 and TRIM71, and their mutations have been linked to diseases. PMID: 26514622
    3. Consistent with the let-7 microRNA stimulatory role of TRIM71 via Lin28B polyubiquitination. PMID: 24602972
    4. poiopi poiopi i90iy9oyu8 PMID: 23892092
    5. The stem cell E3-ligase Lin-41 promotes liver cancer progression through inhibition of microRNA-mediated gene silencing. PMID: 23097274
    6. Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation PMID: 22735451
    7. Repression of human TRIM71 and the zebrafish lin-41 ortholog was abolished when predicted let-7 target sites were mutated. Regulation of TRIM71 expression by let-7 seems to have been evolutionarily conserved. PMID: 17890240

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  • 亚细胞定位：
    Cytoplasm, P-body.
  • 蛋白家族：
    TRIM/RBCC family
  • 组织特异性：
    Specifically expressed in testis.
  • 数据库链接：

    HGNC: 32669

    KEGG: hsa:131405

    STRING: 9606.ENSP00000373272

    UniGene: Hs.113170