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TRIT1 Antibody

  • 货号：
    CSB-PA867142LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: TRIT1 antibody at 3µg/ml
      Lane 1: Jurkat whole cell lysate
      Lane 2: Raji whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 53, 38, 50, 44, 19 kDa
      Observed band size: 53 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA867142LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TRIT1 Polyclonal antibody
  • Uniprot No.：
    Q9H3H1
  • 基因名：
    TRIT1
  • 别名：
    2310075G14Rik antibody; AI314189 antibody; AI314635 antibody; AV099619 antibody; FLJ20061 antibody; hGRO1 antibody; IPP transferase antibody; IPPT antibody; IPT antibody; IPTase antibody; Isopentenyl diphosphate:tRNA isopentenyltransferase antibody; Isopentenyl-diphosphate:tRNA isopentenyltransferase antibody; MGC149242 antibody; MGC149243 antibody; mitochondrial antibody; MOD5 antibody; MOD5_HUMAN antibody; OTTMUSP00000009314 antibody; Putative protein TR2IT1 antibody; RP23-121J14.6 antibody; TRIT 1 antibody; TRIT1 antibody; tRNA dimethylallyltransferase antibody; tRNA isopentenylpyrophosphate transferase antibody; tRNA isopentenyltransferase 1 antibody; tRNA isopentenyltransferase antibody; tRNA isopentenyltransferase mitochondrial antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human tRNA dimethylallyltransferase protein (1-324AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TRIT1 Antibody (CSB-PA867142LA01HU)，的标记方式是Non-conjugated。对于TRIT1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA867142LB01HU TRIT1 Antibody, HRP conjugated ELISA
    FITC CSB-PA867142LC01HU TRIT1 Antibody, FITC conjugated
    Biotin CSB-PA867142LD01HU TRIT1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
  • 基因功能参考文献：
    1. We show that dysfunctional TRIT1 results in decreased levels of select mitochondrial proteins. Our findings confirm the TRIT1 disease association and advance the phenotypic and molecular understanding of this disorder. PMID: 28185376
    2. characterize TRIT1 as a novel human amyloid fiber forming protein. We discuss these data in light of TRIT1's functional roles and possible implications for disease PMID: 27984194
    3. patient cells bearing the p.Arg323Gln TRIT1 mutation are severely deficient in i6A37 in both cytosolic and mitochondrial tRNAs PMID: 24901367
    4. In light of this additional nuclear role for Mod5 we discuss the proposed role of the human homologue of Mod5, TRIT1, as a tumor suppressor protein.[review] PMID: 25261850
    5. TRIT1 may control the levels of some tRNAs as well as their specific activity. PMID: 24126054
    6. One TRIT1 haplotype, CCGT, was associated with lymph node metastasis. PMID: 23349019
    7. The rare allele of TRIT1 Phe202Leu SNP was approximately seven-fold more frequent in Asian than in Caucasian subjects and three additional SNPs in the TRIT1 gene showed ethnic differences in allelic frequencies PMID: 17145094

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  • 亚细胞定位：
    [Isoform 1]: Mitochondrion.; [Isoform 4]: Mitochondrion.; [Isoform 2]: Cytoplasm.; [Isoform 3]: Cytoplasm.; [Isoform 5]: Cytoplasm.
  • 蛋白家族：
    IPP transferase family
  • 数据库链接：

    HGNC: 20286

    OMIM: 617840

    KEGG: hsa:54802

    STRING: 9606.ENSP00000321810

    UniGene: Hs.356554