Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. TRMT5 Antibody

TRMT5 Antibody

  • 中文名称：
    TRMT5兔多克隆抗体
  • 货号：
    CSB-PA024541GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q32P41
  • 基因名：
    TRMT5
  • 别名：
    TRMT5 antibody; KIAA1393 antibody; TRM5 antibody; tRNA antibody; guanine(37)-N1)-methyltransferase antibody; EC 2.1.1.228 antibody; M1G-methyltransferase antibody; tRNA [GM37] methyltransferase antibody; tRNA methyltransferase 5 homolog antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human TRMT5
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
  • 基因功能参考文献：
    1. TRMT5 mutations cause a defect in post-transcriptional modification of mitochondrial tRNA associated with multiple respiratory-chain deficiencies. PMID: 26189817
    2. Conservation of structure and mechanism by Trm5 enzymes PMID: 23887145
    3. comparison of human TRM5 and E Coli TrmD activities, requirements for optimal activity, and tRNA methylation sites PMID: 15248782
  • 相关疾病：
    Combined oxidative phosphorylation deficiency 26 (COXPD26)
  • 亚细胞定位：
    Mitochondrion matrix. Nucleus. Cytoplasm.
  • 蛋白家族：
    Class I-like SAM-binding methyltransferase superfamily, TRM5/TYW2 family
  • 数据库链接：

    HGNC: 23141

    OMIM: 611023

    KEGG: hsa:57570

    STRING: 9606.ENSP00000261249

    UniGene: Hs.380159