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TRPM6 Antibody

  • 货号：
    CSB-PA863139ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA863139ESR1HU at dilution of 1:100
    • Immunofluorescent analysis of 293 cells using CSB-PA863139ESR1HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TRPM6 Polyclonal antibody
  • Uniprot No.：
    Q9BX84
  • 基因名：
    TRPM6
  • 别名：
    TRPM6 antibody; CHAK2Transient receptor potential cation channel subfamily M member 6 antibody; EC 2.7.11.1 antibody; Channel kinase 2 antibody; Melastatin-related TRP cation channel 6 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Transient receptor potential cation channel subfamily M member 6 protein (740-840AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region.
  • 基因功能参考文献：
    1. Results identified high expression of TRPM6 to be indicative of a prolonged overall survival in colorectal patients. Computational analysis suggest that TRPM6 may be targeted by hsalet7g and hsalet7f1. PMID: 30272358
    2. Spectrometric analysis identified phosphorylation sites in TRPM6 protein. PMID: 28220887
    3. Knockout of TRPM6 or inactivation of its kinase results in global changes in histone S/T phosphorylation and changes the transcription of hundreds of genes. PMID: 28784805
    4. Results found that the haplotype containing two common TRPM6 SNPs (rs3750425 and rs2274924) increases the risk for proton pump inhibitor-induced hypomagnesemia. PMID: 27926584
    5. TNF-alpha rescues the EGFR tyrosine kinase inhibitor-induced decrease in TRPM6 expression and Mg2+ influx mediated via the activation of an NF-kappaB signaling pathway. PMID: 27925186
    6. A homozygous frame-shift mutation in the TRPM6 gene is associated with Hereditary hypomagnesemia with secondary hypocalcemia. PMID: 26759217
    7. we showed that two serum magnesium associated loci, MUC1 and TRPM6, had significant effect modification with progestin use and insulin levels, respectively, in European Americans. PMID: 26058915
    8. TRPM6 mRNA and protein levels in atrial fibrillation group were elevated markedly in comparison with sinus rhythm group. PMID: 25796343
    9. Knowledge of TRPM6 functioning is of vital importance to decipher its role in Mg handling and will, in particular, provide a molecular basis for achieving a better understanding of Mg mal(re)absorption and hence systemic Mg balance. PMID: 24906182
    10. We conclude that the new TRPM6 missense mutations lead to dysregulated intestinal/renal Mg(2+) (re)absorption as a consequence of loss of TRPM6 channel function. PMID: 23942199
    11. TRPM6 kinase activity is linked to channel activity through a kinase-independent mechanism involving the dimerization motif binding to a pocket within the kinase domain. PMID: 24650431
    12. Two novel mutations in Chinese sisters with familial hypomagnesemia with secondary hypocalcemia were found: one frameshift mutation (c.1196delC) and one non-sense mutation (c.4577G>A). Both patients were compound heterozygotes for these mutations. PMID: 23689795
    13. PIP2 is required for TRPM6 channel function; hydrolysis of PIP2 by PLC-coupled hormones/agonists may constitute an important pathway for TRPM6 gating, and perhaps Mg2+ homeostasis. PMID: 22180838
    14. Case Report: Resolving basal ganglia calcification in hereditary hypomagnesemia with secondary hypocalcemia due to a novel TRPM6 gene mutation. PMID: 22982920
    15. Loss of insulin-induced activation of TRPM6 magnesium channels results in impaired glucose tolerance during pregnancy PMID: 22733750
    16. A novel mutation of TRPM6 gene is responsible for the development of familial hypommagnesaemia in Turkish children. PMID: 21669885
    17. Results suggest that TRPM6 expression is up-regulated by a PI3K/Akt/mTOR pathway . PMID: 21073857
    18. Loss-of-function mutations cause hypomagnesemia with secondary hypocalcemia. PMID: 20395377
    19. Up-regulation of TRPM6 transcriptional activity by AP-1 in renal epithelial cells. PMID: 19937979
    20. Deficiency /mutations of TRPM6 causes hypomagnesemia with secondary hypocalcemia PMID: 12032568
    21. Individuals with TRPM6 mutations have abnormal renal magnesium excretion. Deficiency causes hypomagnesemia with secondary hypocalcemia. PMID: 12032570
    22. TRPM6 is specifically localized along the apical membrane of the renal distal convoluted tubule and the brush-border membrane of the small intestine and is specific for Mg2+ absoprtion. PMID: 14576148
    23. TRPM6 specifically interacted with its closest homolog, the Mg(2+)-permeable cation channel TRPM7, resulting in the assembly of functional TRPM6/TRPM7 complexes at the cell surface. PMID: 14976260
    24. In patients with primary hypomagnesaemia and secondary hypocalcaemia (HSH), a combined defect of intestinal magnesium absorption and renal magnesium conservation TRPM6 is the first component involved directly in epithelial magnesium reabsorption[review] PMID: 16075242
    25. data demonstrate that amino acid residues E1024, I1030 and D1031 are important for channel function and that subtle amino acid variation in the pore region accounts for TRPM6 permeation properties PMID: 17098283
    26. TRPM6 mutants are found in patients with a rare but severe hereditary disease called hypomagnesaemia with secondary hypocalcaemia --{REVIEW} PMID: 17217065
    27. This review discusses the importance of magnesium in vascular biology and implications in hypertension and highlights the transport systems, particularly TRPM6--REVIEW PMID: 18192217
    28. intracellular ATP regulates TRPM6 channel activity via its alpha-kinase domain independently of alpha-kinase activity PMID: 18490453
    29. diverse molecular regulation of TRPM6 by magnesiotropic hormones, intracellular factors and its fused alpha-kinase domain disclosed novel regulatory mechanisms of active magnesium reabsorption--REVIEW PMID: 18660673
    30. These findings clearly outline the activation of TRPM6 by EGF, a process fundamental to Mg2+ homeostasis. PMID: 19073827
    31. Our results provide suggestive evidence that two common non-synonymous TRPM6 coding region variants, Ile1393Val and Lys1584Glu polymorphisms, might confer susceptibility to type 2 diabetes in women with low magnesium intake PMID: 19149903
    32. REA operates as a negative feedback modulator of TRPM6 in the regulation of active Mg(2+) (re)absorption and provides new insight into the molecular mechanism of renal transepithelial Mg(2+) transport. PMID: 19329436

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  • 相关疾病：
    Hypomagnesemia 1 (HOMG1)
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Alpha-type protein kinase family, ALPK subfamily; Transient receptor (TC 1.A.4) family, LTrpC subfamily, TRPM6 sub-subfamily
  • 组织特异性：
    Highly expressed in kidney and colon. Isoform TRPM6a and isoform TRPM6b, are coexpressed with TRPM7 in kidney, and testis, and are also found in several cell lines of lung origin. Isoform TRPM6c is detected only in testis and in NCI-H510A small cell lung
  • 数据库链接：

    HGNC: 17995

    OMIM: 602014

    KEGG: hsa:140803

    STRING: 9606.ENSP00000354006

    UniGene: Hs.272225