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TSN Antibody

  • 货号：
    CSB-PA004327
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of Jurkat cells using Translin Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q15631
  • 基因名：
    TSN
  • 别名：
    BCLF 1 antibody; BCLF1 antibody; Component 3 of promoter of RISC antibody; RCHF1 antibody; recombination hotspot associated factor antibody; recombination hotspot binding protein antibody; rehf 1 antibody; REHF1 antibody; TBRBP antibody; Translin antibody; TRSLN antibody; TSN antibody; TSN_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Translin.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.; Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
  • 基因功能参考文献：
    1. Translin and Trax control telomere-associated transcript levels in human cells in a telomere-specific fashion. PMID: 27183912
    2. results indicate that UPF1 can dissociate miRNAs from their mRNA targets, making the miRNAs susceptible to Tudor-staphylococcal/micrococcal-like nuclease (TSN)-mediated miRNA decay. PMID: 28827400
    3. These findings indicate that miRNA depletion in dicer deficiency is due to the combined loss of miRNA-generating activity and catabolic function of TN/TX. PMID: 25457613
    4. this study argues against a mechanism by which translin octamers may "dissociate and reassemble" upon RNA binding and report a novel "open"-barrel structure of human translin revealing a feasible DNA/RNA entryway into the cavity. PMID: 25433126
    5. The selectivity of PLCbeta toward certain genes lies in the rate at which the RNA is hydrolyzed by C3PO. PMID: 24338081
    6. The data demonstrates that the configuration of translin and translin-RNA complexes in solution is a dimer of tetramers, which undergoes conformational transitions. PMID: 23980029
    7. Translin B3 motif, corresponding to TRAX B3 residues, contributes towards its DNA binding activity. PMID: 22427937
    8. C3PO endonuclease is an asymmetric octamer barrel consisting of six translin and two TRAX subunits which activates RISC by degrading the Ago2-nicked passenger strand of siRNA. PMID: 21552258
    9. Sedimentation equilibrium studies using fluorescein-labeled single-stranded DNA support a model in which translin forms an annular structure of eight subunits, an oblate ellipsoid that binds single-stranded DNA at chromosomal breakpoints. PMID: 11705401
    10. study of reactivity of two -SH groups and stidu of proximity of Cys-225 residues PMID: 11876655
    11. At high enough concentrations, translin binds duplex DNA by selectively loading from the free ends, which apparently results in clamping of strands at the duplex ends. PMID: 12484770
    12. The core protein of HCV can interact with translin protein. This can partly explain the molecular mechanism for hepatocellular carcinoma and lymphoma caused by HCV PMID: 12532453
    13. TB-RBP post-transcriptionally stabilizes TRAX and both proteins are needed for normal cell proliferation PMID: 14711818
    14. structure of human translin at 2.2 A resolution is reported in space group C222; translin forms a tetramer; this suggests that the multimerization of translin is flexible; the flexibility may be related to the binding to DNA/RNA PMID: 15039555
    15. Results suggest that translin might be involved in the control of recombination at d(GT)n.d(AC)n microsatellites and in telomere maintenance. PMID: 15544804
    16. Translin "chaperones" Trax and forms heteromeric complex that is DNA binding competent PMID: 15919079
    17. Results describe a circular dichroism analysis of complexes formed between human translin and the microsatellite and telomeric oligodeoxynucleotides d(GT)(12) and d(TTAGGG)(5). PMID: 16218753
    18. Human translin exhibits a stable octameric state and binds ssDNA/RNA/dsDNA targets, all of which get attenuated when GTP is added PMID: 16411762
    19. Findings implicate abnormal dendritic trafficking of BDNF mRNA in the pathophysiology of neuropsychiatric disorders linked to the translin G196A mutation. PMID: 19805324

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Translin family
  • 数据库链接：

    HGNC: 12379

    OMIM: 600575

    KEGG: hsa:7247

    STRING: 9606.ENSP00000374332

    UniGene: Hs.75066