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  4. TSPEAR Antibody

TSPEAR Antibody

  • 货号：
    CSB-PA155145
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA155145(TSPEAR Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA155145(TSPEAR Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q8WU66
  • 基因名：
    TSPEAR
  • 别名：
    Thrombospondin-type laminin G domain and EAR repeat-containing protein antibody; TSEAR_HUMAN antibody; TSP-EAR antibody; TSPEAR antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human TSPEAR
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway. May play a role in development or function of the auditory system.
  • 基因功能参考文献：
    1. TSPEAR mutation is associated with tooth agenesis. PMID: 30046887
    2. using a luciferase-based reporter assay, we showed that TSPEAR knock-down is associated with decreased Notch signaling. In addition, NOTCH1 protein expression was reduced in patient scalp skin. Moreover, TSPEAR silencing in mouse hair follicle organ cultures was found to induce apoptosis in follicular epithelial cells, resulting in decreased hair bulb diameter PMID: 27736875
    3. TSPEAR expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
    4. TSPEAR, cause disorders with auditory features: epilepsy, which can include auditory features in humans; audiogenic seizures in animals; and/or hearing impairments in humans and mice. PMID: 22678063
    5. The TSPEAR/C21orf29 promoter is activated by Trichostatin A (TSA) treatment according to promoter reporter assays in HEK 293 cells. PMID: 20494980

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  • 相关疾病：
    Deafness, autosomal recessive, 98 (DFNB98)
  • 亚细胞定位：
    Secreted. Cell surface. Cell projection, stereocilium.
  • 数据库链接：

    HGNC: 1268

    OMIM: 612920

    KEGG: hsa:54084

    STRING: 9606.ENSP00000321987

    UniGene: Hs.660703