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TUB Antibody

  • 货号：
    CSB-PA025305GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P50607
  • 基因名：
    TUB
  • 别名：
    F10B5.4 antibody; rd5 antibody; TUB 1 antibody; TUB antibody; TUB_HUMAN antibody; Tubby homologue antibody; Tubby protein homolog 1 antibody; Tubby protein homolog antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human TUB
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight. Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.
  • 基因功能参考文献：
    1. Tubby and Tulp1 mediated phagocytosis through MerTK-dependent signaling with non-muscle myosin II redistribution leading to colocalization of phagocytosed vesicles with rearranged NMMIIA. PMID: 24664737
    2. Tubby and Tulp1 are bridging molecules with their N-terminal region as MERTK-binding domain and C-terminal region as phagocytosis prey-binding domain. PMID: 20978472
    3. Tubby and Tulp1 function as phagocytosis sigmals (eat-me) for retinal pigment epithelium cells and other phagocytes. PMID: 19837063
    4. TUB could be an important factor in controlling the central regulation of body weight in humans. PMID: 16443771
    5. found the presence of tubby protein both in normal weight and in obese subjects; however in the latter an isoelectric point shift toward the acidic end was observed PMID: 17498679
    6. TUB is a candidate gene for late-onset obesity in humans PMID: 17955208
    7. Genetic variation of the TUB gene was associated with both body composition and macronutrient intake, suggesting that TUB might influence eating behavior PMID: 18183286
    8. Mouse Tubby protein may function as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, providing a direct link between G-protein signaling and the regulation of gene expression. PMID: 11375483
    9. Crystal structure of the core domain of the mouse Tubby protein. PMID: 10591637

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  • 相关疾病：
    Retinal dystrophy and obesity (RDOB)
  • 亚细胞定位：
    Cytoplasm. Nucleus. Secreted. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    TUB family
  • 数据库链接：

    HGNC: 12406

    OMIM: 601197

    KEGG: hsa:7275

    STRING: 9606.ENSP00000305426

    UniGene: Hs.568986