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TUBA1B Antibody

  • 货号：
    CSB-PA910224
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from Hela and HT29 cells using alpha-Tubulin Antibody .
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TUBA1B Polyclonal antibody
  • Uniprot No.：
    P68363
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Peptide sequence around aa.437-441(V-D-S-V-E) derived from Human alpha-Tubulin.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
  • 基因功能参考文献：
    1. Data show that retinal endothelial cells (HREC) treated with low molecular weight fraction of commercial 5% human serum albumin (LMWF5A) exhibit a rapid increase in the amount and distribution of acetylated alpha-tubulin. PMID: 27613088
    2. The C-terminal tail from the tubulin beta I isotype, but not the beta III isotype, formed contacts in the putative binding site of a recently discovered antineoplastic peptide that disrupts microtubule formation in glioma cells. PMID: 28290671
    3. TUBA1B/ESR1 gene interaction might play pivotal roles in the occurrence and development of Postmenopausal Osteoporosis. PMID: 26676054
    4. Taken together our data provide valuable information regarding the interaction of CK1delta and a-tubulin and a novel approach for the development of pharmacological tools to inhibit proliferation of cancer cells. PMID: 26996302
    5. Results suggest that lithium chloride (LiCl) treatments activate alpha-tubulin N-acetyltransferase 1 (alphaTAT1) by the inhibition of glycogen synthase kinase 3 beta (GSK-3beta) and promote the alpha-tubulin acetylation, and then elongate the primary cilia. PMID: 24760594
    6. NAD-dependent regulation of alpha-tubulin acetylation is mediated by SIRT2. PMID: 24814981
    7. Data indicate that the derivatives exhibited much better potency to inhibit tubulin polymerization but a decreased activity to inhibit Hsp27 chaperone function. PMID: 23767669
    8. Increased TUBA1B expression is associated with poor overall survival in hepatocellular carcinoma. PMID: 23625295
    9. ARHGAP21 is a Rho-GAP involved in cell-cell junction remodeling that affects migration and EMT through alpha-tubulin interaction and acetylation PMID: 23235160
    10. TQ induced a concentration- and time-dependent degradation of alpha/beta tubulin in both cancer cell types. PMID: 21881916
    11. the ethyl acetate extract of Lactuca sativa induced HL-60 cell death, which correlated with the acetylation of alpha-tubulin. PMID: 20204303
    12. Confocal microscopic analyses showed co-localization of the TaSP protein with alpha-tubulin and reciprocal immuno-co-precipitation experiments demonstrated an association of TaSP with alpha-tubulin in vivo. PMID: 20162433
    13. This protein has been found differentially expressed in the anterior cingulate cortex from patients with schizophrenia PMID: 20381070
    14. increased levels in paclitaxel-resistant breast cancer cells PMID: 12054644
    15. Candidate gene K-ALPHA-1 expression in malignant and non-malignant prostate tissue samples after microdissection. PMID: 17628775
    16. accumulation of alpha-synuclein might contribute to the pathogenesis of PD and other Lewy body diseases by promoting alterations in parkin and tubulin solubility PMID: 18195004
    17. N-terminal sequencing and blastx analysis as well as blocking with K-alpha1 tubulin-specific Ab identified the epithelial Ag as K-alpha1 tubulin[K-alpha1 tubulin] PMID: 18354170
    18. These results imply that MeCP2 is involved in the regulation of neuronal alpha-tubulin and add molecular evidence that reversal of the effects of MeCP2 deficiency is achievable PMID: 19174478
    19. Increased expression of centrosomal TUBA1B in atypical ductal hyperplasia and carcinoma of the breast is reported. PMID: 19215229
    20. alpha-tubulin interacted with ARL7. PMID: 19409876
    21. This protein has been found differentially expressed in the Wernicke's Area from patients with schizophrenia. PMID: 19405953

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Tubulin family
  • 数据库链接：

    HGNC: 18809

    OMIM: 602530

    KEGG: hsa:10376

    STRING: 9606.ENSP00000336799

    UniGene: Hs.524390