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TUBA4A Antibody

  • 货号：
    CSB-PA09499A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: NIH/3T3 whole cell lysate, K562 whole cell lysate, Mouse brain tissue
      All lanes: TUBA4A antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 50, 49 kDa
      Observed band size: 50, 24 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA09499A0Rb at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA09499A0Rb at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA09499A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Immunoprecipitating TUBA4A in K562 whole cell lysate
      Lane 1: Rabbit control IgG instead of (1μg) instead of CSB-PA09499A0Rb in K562 whole cell lysate. For western blotting, a HRP-conjugated light chain specific antibody was used as the Secondary antibody (1/50000)
      Lane 2: CSB-PA09499A0Rb (4μg) + K562 whole cell lysate (500μg)
      Lane 3: K562 whole cell lysate (20μg)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TUBA4A Polyclonal antibody
  • Uniprot No.：
    P68366
  • 基因名：
  • 别名：
    Alpha-tubulin 1 antibody; ALS22 antibody; B ALPHA 1 antibody; bA408E5.3 antibody; H2 ALPHA antibody; Hum a tub1 antibody; Hum a tub2 antibody; LIS3 antibody; MGC171407 antibody; MGC55332 antibody; TBA4A_HUMAN antibody; Testis-specific alpha-tubulin antibody; TUBA1 antibody; TUBA1A antibody; tuba1l antibody; Tuba4a antibody; Tubulin alpha 1 chain antibody; Tubulin alpha antibody; Tubulin alpha-1 chain antibody; tubulin alpha-1B chain antibody; Tubulin alpha-4A chain antibody; Tubulin H2-alpha antibody; Tubulin, alpha 1 (testis specific) antibody; tubulin, alpha 1, like antibody; Tubulin, alpha 4a antibody; Tubulin, alpha, testis-specific antibody; Tubulin, alpha-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Tubulin alpha-4A chain protein (20-183AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TUBA4A Antibody (CSB-PA09499A0Rb)，的标记方式是Non-conjugated。对于TUBA4A Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA09499B0Rb TUBA4A Antibody, HRP conjugated ELISA
    FITC CSB-PA09499C0Rb TUBA4A Antibody, FITC conjugated
    Biotin CSB-PA09499D0Rb TUBA4A Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF, IP
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
    IP 1:200-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
  • 基因功能参考文献：
    1. Data indicate a microRNA-1825/TBCB/TUBA4A pathway as a putative pathogenic cascade in both familial ALS (fALS) and both sporadic (sALS). PMID: 30030593
    2. The elevated selenium species levels in the TUBA4A patient may have a genetic etiology and/or represent a pathogenic pathway through which this mutation favors disease onset. PMID: 28478440
    3. alphaTubulin expression might be an independent prognostic factor for pancreatic cancer after surgical resection PMID: 27447976
    4. Its mutations were seen in patients with ALS and frontotemporal dementia. PMID: 28069311
    5. TUBA4A mutations are not associated with FTD. PMID: 26675813
    6. In conclusion, our current results did not find an association between TUBA4A and ALS in Chinese patients, and further studies will be required. PMID: 26465396
    7. This study mutational screening revealed the presence of four novel heterozygous variants of TUBA4A mutation in four sporadic amyotrophic lateral sclerosis. PMID: 25893256
    8. Data show that overexpression of the 14-3-3sigma isoform resulted in a disruption of the tubulin cytoskeleton mediated by binding Tau protein. PMID: 26103986
    9. TUBA4A mutants destabilize the microtubule network, diminishing its repolymerization capability PMID: 25374358
    10. TUBA4A is significantly increased in spermatazoa from men with azoospermia. PMID: 24268707
    11. The results suggested that cytoskeletal alterations in the amygdala determined by tubulin seem to be involved in the pathophysiology of drug addiction PMID: 20686780
    12. Subunits of alphaB crystallin that exchange dynamically with the alphaB crystallin complex can interact with tubulin subunits to regulate the equilibrium between tubulin and microtubules. PMID: 20668689
    13. increased levels in paclitaxel-resistant breast cancer cells PMID: 12054644
    14. Some protein-protein interactions in rafts were disrupted in 3-nitrotyrosine-containing proteins, e.g. caveolin-1 was dissociated from a complex with flotillin-1 and alpha-tubulin. PMID: 15934946
    15. Our results suggest that MIZIP might play an important role in mammalian cells by associating with tubulin and thus might provide a link between MCHR1 and tubulin functions. PMID: 16039987
    16. These results provide the first characterisation of endogenously nitrated tubulin from human tumour samples. PMID: 16257120

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  • 相关疾病：
    Amyotrophic lateral sclerosis 22, with or without frontotemporal dementia (ALS22)
  • 亚细胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Tubulin family
  • 数据库链接：

    HGNC: 12407

    OMIM: 191110

    KEGG: hsa:7277

    STRING: 9606.ENSP00000248437

    UniGene: Hs.75318