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TWF1 Antibody

  • 货号：
    CSB-PA622511LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA622511LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA622511LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TWF1 Polyclonal antibody
  • Uniprot No.：
    Q12792
  • 基因名：
    TWF1
  • 别名：
    A6 antibody; A6 protein tyrosine kinase antibody; MGC105817 antibody; MGC23788 antibody; MGC41876 antibody; Protein A6 antibody; Protein tyrosine kinase 9 antibody; PTK9 antibody; PTK9 protein tyrosine kinase 9 antibody; TWF 1 antibody; twf1 antibody; TWF1_HUMAN antibody; Twinfilin 1 antibody; Twinfilin actin binding protein, homolog 1 antibody; Twinfilin antibody; Twinfilin, actin-binding protein, homolog 1 (Drosophila) antibody; Twinfilin, Drosophila, homolog of, 1 antibody; Twinfilin-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Twinfilin-1 protein (199-252AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TWF1 Antibody (CSB-PA622511LA01HU)，的标记方式是Non-conjugated。对于TWF1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA622511LB01HU TWF1 Antibody, HRP conjugated ELISA
    FITC CSB-PA622511LC01HU TWF1 Antibody, FITC conjugated
    Biotin CSB-PA622511LD01HU TWF1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles.
  • 基因功能参考文献：
    1. Univariate Cox regression analysis showed high expression of TWF1 to be independent prognostic indicator involved in overall survival and recurrence-free survival in lung adenocarcinoma, but not in lung squamous cell carcinoma PMID: 30391462
    2. TWF1 and VIM are required for miR-30c to regulate breast cancer cell invasion. PMID: 23224145
    3. An interleukin-6 family member, interleukin-11 is identified as a secondary target of twinfilin 1 in the microRNA-30c signalling pathway. PMID: 23340433
    4. protein overexpression promotes cardiomyocyte hypertrophy PMID: 20571053
    5. These data suggest that the association with an actin monomer induces a first-order conformational change within the twinfilin molecule. PMID: 12429826
    6. mammals have two twinfilin isoforms, which are differentially expressed and regulated through distinct cellular signaling pathways PMID: 12807912

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  • 相关疾病：
    Defects in TWF1 has been found in a patient with isolated coloboma, a defect of the eye characterized by the absence of ocular structures due to abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Isolated colobomas may be associated with an abnormally small eye (microphthalmia) or small cornea.
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Actin-binding proteins ADF family, Twinfilin subfamily
  • 组织特异性：
    Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver.
  • 数据库链接：

    HGNC: 9620

    OMIM: 610932

    KEGG: hsa:5756

    STRING: 9606.ENSP00000449428

    UniGene: Hs.189075