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TXNL1 Antibody

  • 货号：
    CSB-PA025384GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O43396
  • 基因名：
    TXNL1
  • 别名：
    32 kDa thioredoxin related protein antibody; 32 kDa thioredoxin-related protein antibody; Thioredoxin like 1 antibody; Thioredoxin like 32kD antibody; Thioredoxin like 32kDa antibody; Thioredoxin like protein 1 antibody; Thioredoxin related 32 kDa protein antibody; Thioredoxin-like protein 1 antibody; TRP 32 antibody; TRP32 antibody; TRxL antibody; TXL 1 antibody; TXL antibody; TXL1 antibody; TXN L1 antibody; TXNL 1 antibody; TXNL antibody; Txnl1 antibody; TXNL1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human TXNL1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Active thioredoxin with a redox potential of about -250 mV.
  • 基因功能参考文献：
    1. TXNL1 is a novel regulatory molecule that inhibits cisplatin resistance in gastric cancer cells. PMID: 24525731
    2. Distinct protein expression patterns, affecting TXNL1 and HDAC2, distinguish aneuploid with poor prognosis from diploid colorectal cancers. PMID: 21290163
    3. Solution structure of the C-terminal DUF1000 domain of the human thioredoxin-like 1 protein. PMID: 20455272
    4. results imply that TRP-1 is a mammalian thioredoxin and plays as a transcriptional repressor through direct binding to the transcription factor B-Myb PMID: 16231315
    5. TXNL1 acts as an effector of oxidants or a redox sensor by converting redox changes into changes of GDI capacity to capture Rab5, which in turn modulates fluid phase endocytosis PMID: 17987124
    6. Txnl1 is the first example of a direct connection between protein reduction and proteolysis, two major intracellular protein quality control mechanisms. PMID: 19349277
    7. TRP32 was identified as a novel subunit of the 26 S proteasome. PMID: 19349280

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=At least 85% of the cellular TXNL1 is proteasome-associated.
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 12436

    OMIM: 603049

    KEGG: hsa:9352

    STRING: 9606.ENSP00000217515

    UniGene: Hs.114412