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UBA7 Antibody

  • 货号：
    CSB-PA991105
  • 规格：
    ￥2024
  • 图片：
    • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using UBE1L antibody.
    • Western blot analysis of extracts from HeLa cells, using UBE1L antibody.
    • Western blot analysis of extracts from JK cells (Lane 2), using UBE1L antiobdy. The lane on the left is treated with synthesized peptide.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) UBA7 Polyclonal antibody
  • Uniprot No.：
    P41226
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from C-terminal of Human UBE1L.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein.
  • 基因功能参考文献：
    1. RNF170, an endoplasmic reticulum (ER)-associated ubiquitin E3 ligase, interacted with pUL50 and promoted pUL50-mediated UBE1L degradation via ubiquitination. PMID: 29743376
    2. the cellular effects of progerin expression in Hutchinson-Gilford progeria syndrome are transduced, at least in part, through reduced function of the Ran GTPase and E2 SUMOylation pathways. PMID: 21670151
    3. Observational study and meta-analysis of gene-disease association. (HuGE Navigator) PMID: 20601676
    4. UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia PMID: 11891284
    5. RA treatment of APL and other RA-responsive leukemic cells induced expression of UBE1L and ISG15 as well as intracellular ISG15 conjugates. A physical association was found between UBE1L and ISG15 in vivo. PMID: 14976209
    6. Ube1L was required for transfer of ISG15 to UbcH8 and for binding of Ube1L to UbcH8 PMID: 18583345
    7. UBE1L-ISG15 preferentially inhibits cyclin D1 in lung cancer PMID: 19074853

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  • 蛋白家族：
    Ubiquitin-activating E1 family
  • 组织特异性：
    Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines.
  • 数据库链接：

    HGNC: 12471

    OMIM: 191325

    KEGG: hsa:7318

    STRING: 9606.ENSP00000333266

    UniGene: Hs.16695