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UBASH3A Antibody

  • 货号：
    CSB-PA025427LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescent analysis of HepG2 cells using CSB-PA025427LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: K562 whole cell lysate, HL60 whole cell lysate, Hela whole cell lysate, Rat heart tissue
      All lanes: UBASH3A antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 75, 70, 60 kDa
      Observed band size: 70 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) UBASH3A Polyclonal antibody
  • Uniprot No.：
    P57075
  • 基因名：
    UBASH3A
  • 别名：
    Cbl interacting protein 4 antibody; Cbl-interacting protein 4 antibody; CLIP4 antibody; STS 2 antibody; STS-2 antibody; Suppressor of T cell receptor signaling 2 antibody; Suppressor of T-cell receptor signaling 2 antibody; T cell ubiquitin ligand antibody; T cell ubiquitin ligand protein antibody; T-cell ubiquitin ligand 1 antibody; TULA antibody; TULA-1 antibody; UBASH3A antibody; ubiquitin associated and SH3 domain containing, A antibody; Ubiquitin-associated and SH3 domain-containing protein A antibody; UBS3A_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Ubiquitin-associated and SH3 domain-containing protein A protein (287-455AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，UBASH3A Antibody (CSB-PA025427LA01HU)，的标记方式是Non-conjugated。对于UBASH3A Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA025427LB01HU UBASH3A Antibody, HRP conjugated ELISA
    FITC CSB-PA025427LC01HU UBASH3A Antibody, FITC conjugated
    Biotin CSB-PA025427LD01HU UBASH3A Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.
  • 基因功能参考文献：
    1. UBASH3A gene SNP is associated with susceptibility to atopic dermatitis in Chinese Han population. PMID: 28747736
    2. UBASH3A attenuates the NF-kappaB signal transduction upon T-cell receptor (TCR) stimulation by specifically suppressing the activation of the IkappaB kinase complex. UBASH3A interacts with TAK1 and NEMO, suggesting that UBASH3A regulates the NF-kappaB signaling pathway by an ubiquitin-dependent mechanism. T1D risk alleles at rs11203203 and rs80054410 increase UBASH3A expression in CD4(+) T cells upon TCR stimulation. PMID: 28607106
    3. A negative correlation was found between UBASH3A mRNA expression and systemic lupus erythematosus. PMID: 25876712
    4. Findings suggest that UBASH3A gene might contribute to systemic lupus erythematosus susceptibility and influence the clinical phenotype of the disease. PMID: 25843625
    5. these results have suggested that the allele A of two SNPs may play no role in the pathogenesis of autoimmune thyroid disease or that its effect may be confounded by other various factors. PMID: 25211447
    6. Addition of PTPN22 and UBASH3A SNPs to HLA-DR,DQ genotyping can improve type 1 diabetes risk prediction. PMID: 25075402
    7. Results suggest that UBASH3a gene plays a role in the susceptibility to systemic lupus erythematosus and UBASH3a can be considered as a common genetic factor in autoimmune diseases. PMID: 23565265
    8. ubiquitin associated and SH3 domain containing A appears to be an independent predictor of islet autoimmunity and type 1 diabetes in children, including those free of family history of T1D but carrying the HLA-DR3/4,DQB1*0302 genotype PMID: 22776074
    9. The UBASH3A promoter is activated by serum depletion according to promoter reporter assays in HEK 293 cells. PMID: 20494980
    10. Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases PMID: 15159412
    11. TULA inhibits both clathrin-dependent and clathrin-independent endocytic pathways by functionally sequestering dynamin via the SH3 domain of TULA binding proline-rich sequences in dynamin PMID: 17382318
    12. TULA enhances the apoptotic effect of AIF by facilitating the interactions of AIF with its apoptotic co-factors PMID: 17709377
    13. Binds to ABCE-1 and inhibits HIV-1 life cycle, most likely by disrupting essential ubiquitylation-dependent events. PMID: 18006034
    14. TULA proteins TULA and TULA-2 regulate activity of the protein tyrosine kinase Syk PMID: 18189269

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 组织特异性：
    Highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, thymus and bone marrow.
  • 数据库链接：

    HGNC: 12462

    OMIM: 605736

    KEGG: hsa:53347

    STRING: 9606.ENSP00000317327

    UniGene: Hs.473912