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UBE2A Antibody

  • 货号：
    CSB-PA025438GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P49459
  • 基因名：
  • 别名：
    BHR6A antibody; hHR6A antibody; HR6A antibody; mHR6A antibody; MRXS30 antibody; MRXSN antibody; RAD6 homolog A antibody; RAD6A antibody; UBC2 antibody; UBCD6 antibody; UBE2A antibody; Ube2a ubiquitin-conjugating enzyme E2A antibody; UBE2A_HUMAN antibody; Ubiquitin carrier protein A antibody; Ubiquitin carrier protein antibody; Ubiquitin conjugating enzyme E2 17 kDa antibody; Ubiquitin conjugating enzyme E2 21.5 kDa antibody; Ubiquitin conjugating enzyme E2A (RAD6 homolog) antibody; Ubiquitin conjugating enzyme E2A antibody; Ubiquitin protein ligase A antibody; Ubiquitin-conjugating enzyme E2 A antibody; Ubiquitin-protein ligase A antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human UBE2A
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.
  • 基因功能参考文献：
    1. RAD6 is upregulated in response to chemotherapy and significantly correlated with expression of ovarian cancer (OC) stem cell signaling genes ALDH1A1 and SOX2 and poor prognosis of OC patients. PMID: 28806395
    2. RAD6 promotes proteasome activity and nuclear translocation by enhancing the degradation of PSMF1 and the lamin B receptor. PMID: 28031328
    3. Data show that the ubiquitin-conjugating enzyme E2 RAD6A/B-MDM2 ubiquitin ligase machinery regulates anti-silencing function 1A protein (ASF1A) degradation. PMID: 26336826
    4. Results showed KCMF1 C-terminus binds directly to RAD6, whereas N-terminal domains interact with UBR4 and point mutations found in X-linked intellectual disability (XLID) patients specifically lose the interaction with KCMF1 and UBR4. PMID: 25582440
    5. This study investigates clinical and molecular data of two unrelated, affected males with chromosome Xq24 deletions encompassing UBE2A. PMID: 25287747
    6. RAD6 physically interacts with heterochromatin protein 1alpha and ubiquitinates HP1alpha at residue K154, thereby promoting heterochromatin protein 1alpha degradation through the autophagy pathway PMID: 25384975
    7. HHR6 and hRad18 can monoubiquitinate FANCD2 at lysine 561 in vitro. This activity may represent a novel stress response pathway. PMID: 24036990
    8. RNF168, in complex with RAD6A or RAD6B, is activated in the DNA-damage-induced protein ubiquitination cascade. PMID: 23525009
    9. RAD6A is a regulator of Parkin-dependent mitophagy plays a critical role in maintaining neuronal function. PMID: 23685073
    10. UBE2A specifically interacts with CDK9, but not CDK2 and is phosphorylated by CDK9 in vitro. PMID: 22592529
    11. RAD6 can form a ternary complex with MDM2 and p53 that contributes to the degradation of p53. PMID: 22083959
    12. UBE2A deficiency syndrome is reported in two male patients. PMID: 21108393
    13. showed that the function of FA signaling pathway is at least partly mediated through coupling with hRad6/hRad18 signaling (HHR6 pathway) PMID: 20967207
    14. Novel missense mutations in the ubiquitination-related gene UBE2A cause a recognizable X-linked mental retardation syndrome PMID: 20412111
    15. high resolution backbone structure from nmr PMID: 11885984
    16. A single-nucleotide substitution, c.382C-->T in UBE2A, led to a premature UAG stop codon (Q128X). This is the first description of a mutation in a ubiquitin-conjugating enzyme gene as the cause of a human disease. PMID: 16909393

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  • 相关疾病：
    Mental retardation, X-linked, syndromic, Nascimento-type (MRXSN)
  • 蛋白家族：
    Ubiquitin-conjugating enzyme family
  • 数据库链接：

    HGNC: 12472

    OMIM: 300860

    KEGG: hsa:7319

    STRING: 9606.ENSP00000360613

    UniGene: Hs.379466