UBE2D3 Antibody
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) UBE2D3 Polyclonal antibody
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Uniprot No.:P61077
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基因名:
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别名:E2(17)KB3 antibody; MGC43926 antibody; MGC5416 antibody; PRO2116 antibody; UB2D3_HUMAN antibody; UBC 4/5 antibody; UBC4/5 antibody; UBC4/5 homolog yeast antibody; UBC4/5, S. cerevisiae, homolog of antibody; UBCH 5C antibody; UBCH5C antibody; Ube2d3 antibody; Ubiquitin carrier protein antibody; Ubiquitin carrier protein D3 antibody; Ubiquitin conjugating enzyme E2 17 kDa 3 antibody; Ubiquitin conjugating enzyme E2 D3 antibody; Ubiquitin conjugating enzyme E2D 3 (homologous to yeast UBC4/5) antibody; Ubiquitin conjugating enzyme E2D 3 (UBC4/5 homolog yeast) antibody; Ubiquitin conjugating enzyme E2D 3 antibody; Ubiquitin protein ligase D3 antibody; Ubiquitin-conjugating enzyme E2 D3 antibody; Ubiquitin-conjugating enzyme E2(17)KB 3 antibody; Ubiquitin-conjugating enzyme E2-17 kDa 3 antibody; Ubiquitin-protein ligase D3 antibody
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宿主:Rabbit
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反应种属:Human, Rat
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免疫原:Recombinant Human Ubiquitin-conjugating enzyme E2 D3 protein (1-147AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
本页面中的产品,UBE2D3 Antibody (CSB-PA025445HA01HU),的标记方式是Non-conjugated。对于UBE2D3 Antibody,我们还提供其他标记。见下表:
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:>95%, Protein G purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
产品提供形式:Liquid
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应用范围:ELISA, WB
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推荐稀释比:
Application Recommended Dilution WB 1:500-1:5000 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相关产品
靶点详情
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功能:Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts ...显示更多
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基因功能参考文献:
- Together with Riplet, Ube2D3 promotes covalent conjugation of polyubiquitin chains to RIG-I, while Ube2N preferentially facilitates production of unanchored chains. In the presence of these chains, RIG-I induces MAVS aggregation directly on the mitochondria. Data thus reveal two essential mechanisms underlying the activation of RIG-I and MAVS for triggering innate immune signaling in response to viral infection in cells. PMID: 28469175
- Findings indicate that UBE2D3 enhances radiosensitivity of EC109 cells by degradating hTERT through the ubiquitin proteolysis pathway. PMID: 27105523
- This study demonistrated by Gene expression profile that UBE3D3 upregulaion in fibroblasts of Huntington's disease patients. PMID: 24296361
- These data reveal novel insights into the Otub1 inhibition of E2 wherein monoubiquitination promotes the interaction of Otub1 with UbcH5 and the function to suppress it. PMID: 24403071
- UBE2D3 participates in the process of radiosensitivity in human breast cancer cells by regulating TERT and cyclin D1. PMID: 23741361
- although a reduction in interdomain dynamics of UbcH5c~Ub is observed upon binding to E4B, Ub retains an extensive degree of flexibility PMID: 23550736
- The crystal structure of a complex of the Bmi1/Ring1b RING-RING heterodimer & UbcH5c shows that UbcH5c interacts with Ring1b only. PMID: 21772249
- UbcH5c approximately Ub conjugate populates an array of extended conformations, and the population of Ubc13 approximately Ub conjugates favors a closed conformation in which the hydrophobic surface of Ub faces helix 2 of Ubc13 PMID: 21226485
- determined structures of E4B U box free and bound to UbcH5c and Ubc4 E2s; findings show E4B U box is a monomer stabilized by a network of hydrogen bonds; findings suggest allosteric regulation of UbcH5c and Ubc4 by E4B U box PMID: 20696396
- Combined Actions of UbcH5c and Cdc34 Promote Rapid and Efficient Polyubiquitination of IkBa PMID: 20347421
- Transducin beta-gamma is a substrate of UbcH5c (UBE2D3), UbcH7 (UBE2L3) and the ubiquitin-proteasome pathway only following the dissociation of transducin alpha from beta-gamma. Transducin beta-gamma is protected from ubiquitylation by phosducin. PMID: 12215439
- Knocking down UBE2D3 by RNA interference leads to blockage oof retinoic acid induced chclin D1 degradation and cell cycle arrest. PMID: 17420285
- These results suggest that UbcH5 regulates ZIPK accumulation in PML-NBs by interacting with ZIPK and stimulating its ubiquitination. PMID: 18515077
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亚细胞定位:Cell membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
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蛋白家族:Ubiquitin-conjugating enzyme family
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数据库链接:
HGNC: 12476
OMIM: 602963
KEGG: hsa:7323
UniGene: Hs.518773