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UBE2E2 Antibody

  • 中文名称：
    UBE2E2兔多克隆抗体
  • 货号：
    CSB-PA025449GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q96LR5
  • 基因名：
    UBE2E2
  • 别名：
    FLJ25157 antibody; UB2E2_HUMAN antibody; UBC4/5 homolog yeast antibody; UBCH 8 antibody; UbcH8 antibody; Ube2e2 antibody; Ubiquitin carrier protein E2 antibody; Ubiquitin conjugating enzyme E2 E2 antibody; Ubiquitin conjugating enzyme E2E 2 (homologous to yeast UBC4/5) antibody; Ubiquitin conjugating enzyme E2E 2 (UBC4/5 homolog yeast) antibody; Ubiquitin conjugating enzyme E2E 2 antibody; Ubiquitin protein ligase E2 antibody; Ubiquitin-conjugating enzyme E2 E2 antibody; Ubiquitin-protein ligase E2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human UBE2E2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein.
  • 基因功能参考文献：
    1. changes in methylation rates in umbilical cord samples were associated with the proportion of Firmicutes in the maternal gut PMID: 27863092
    2. We investigated the modification of air pollution and diabetes association by a genetic risk score covering 63 T2D genes. Five single variants near GRB14, UBE2E2, PTPRD, VPS26A and KCNQ1 showed nominally significant interactions with PM10 (P<0.05). Our results suggest that genetic risk for T2D may modify susceptibility to air pollution through alterations in insulin sensitivity. PMID: 27281273
    3. Ube2e2 underexpression is associated with metabolic diseases. PMID: 27918534
    4. After adjustment for age, sex, and BMI, rs163182 in KCNQ1 and rs7612463 in UBE2E2 were found to be associated with Type 2 Diabetes Mellitus risk in Chinese Han population. PMID: 27175665
    5. rs7612463 UBE2E2 single nucleotide polymorphism is associated with type 2 diabetes mellitus in a Chinese Han population. PMID: 26020062
    6. Study found lack of association between UBE2E2 gene polymorphism (rs7612463) and type 2 diabetes mellitus in a Saudi population PMID: 25337779
    7. The genetic variants of UBE2E2 are associated with gestational diabetes mellitus and fasting blood glucose. PMID: 23862583
    8. Single nucleotide polymorphism in UBE2E2 is associated with type 2 diabetes. PMID: 20818381
    9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    10. Siah proteins function as E3 ubiquitin-protein ligases PMID: 11786535
    11. Ubc8 is a major ISG15-conjugating enzyme responsible for protein ISGylation upon interferon stimulation PMID: 15485925
    12. Ubiquitin charging can function as a nuclear import trigger, and identify a novel link between E2 regulation and karyopherin-mediated transport. PMID: 15545318

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  • 蛋白家族：
    Ubiquitin-conjugating enzyme family
  • 数据库链接：

    HGNC: 12478

    OMIM: 602163

    KEGG: hsa:7325

    STRING: 9606.ENSP00000379931

    UniGene: Hs.475688