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UBE2G2 Antibody

  • 货号：
    CSB-PA025454LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: UBE2G2 antibody at 8µg/ml + K562 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 19, 16 kDa
      Observed band size: 19 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA025454LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA025454LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) UBE2G2 Polyclonal antibody
  • Uniprot No.：
    P60604
  • 基因名：
  • 别名：
    Human ubiquitin conjugating enzyme G29 antibody; UB2G2_HUMAN antibody; UBC 7 antibody; UBC7 antibody; UBC7 homolog yeast antibody; UBE2G2 antibody; Ubiquitin carrier protein G2 antibody; Ubiquitin conjugating enzyme 7 antibody; Ubiquitin conjugating enzyme E2 G2 antibody; Ubiquitin conjugating enzyme E2G 2 (homologous to yeast UBC7) antibody; Ubiquitin conjugating enzyme E2G 2 (UBC7 homolog yeast) antibody; Ubiquitin conjugating enzyme E2G 2 (UBC7 homolog; yeast) antibody; Ubiquitin conjugating enzyme E2G 2 antibody; Ubiquitin conjugating enzyme G2 antibody; Ubiquitin protein ligase G2 antibody; Ubiquitin-conjugating enzyme E2 G2 antibody; Ubiquitin-protein ligase G2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Ubiquitin-conjugating enzyme E2 G2 protein (1-165AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，UBE2G2 Antibody (CSB-PA025454LA01HU)，的标记方式是Non-conjugated。对于UBE2G2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA025454LB01HU UBE2G2 Antibody, HRP conjugated ELISA
    FITC CSB-PA025454LC01HU UBE2G2 Antibody, FITC conjugated
    Biotin CSB-PA025454LD01HU UBE2G2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). Required for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation.
  • 基因功能参考文献：
    1. UBE2G2 was crucial for the degradation of various immunoreceptors. UBE2J2, on the other hand, counteracted US2-induced endoplasmic reticulum-associated protein degradation by downregulating TRC8 expression. PMID: 28743740
    2. Further study discovered that the gp78 CUE domain works as a proofreading machine during the growth of K48-linked polyubiquitin chains to ensure the linkage specificity. Together, our studies uncover a novel mechanism underlying the linkage specificity determination of longer polyubiquitin chains. PMID: 27067047
    3. The presence of the AUP1-Ube2g2 complex at LDs provides a direct molecular link between LDs and the cellular ubiquitination machinery. PMID: 21127063
    4. Lys-48-linked polyubiquitin chains may be designed to bind certain proteins like Ube2g2 such that the terminal ubiquitin subunit carrying the reactive Lys-48 side chain can be positioned properly for chain elongation regardless of chain length. PMID: 21098018
    5. Results report the solution structure and backbone dynamics of Ube2g2 solved by nuclear magnetic resonance spectroscopy. PMID: 20014027
    6. Ubc7 mediates inositol 1,4,5-trisphosphate receptor ubiquitination and is a component of the endoplasmic reticulum-associated degradation pathway PMID: 12869571
    7. interrupting a specific E2-E3 interaction can selectively inhibit endoplasmic reticulum -associated degradation PMID: 16407162
    8. Structural comparison of human UBE2G2 with yeast Ubc7 indicated that the overall structures are similar except for the long loop region and the C-terminal helix. PMID: 16582478

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  • 亚细胞定位：
    Endoplasmic reticulum. Lipid droplet.
  • 蛋白家族：
    Ubiquitin-conjugating enzyme family
  • 数据库链接：

    HGNC: 12483

    OMIM: 603124

    KEGG: hsa:7327

    STRING: 9606.ENSP00000338348

    UniGene: Hs.529420