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  4. UBE2O Antibody

UBE2O Antibody

  • 货号：
    CSB-PA025473GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9C0C9
  • 基因名：
  • 别名：
    E2 230K antibody; EC=6.3.2.19 antibody; FLJ12878 antibody; KIAA1734 antibody; Likely Ortholog of Mouse Ubiquitin Conjugating Enzyme antibody; RP23 193A16.5 antibody; UBE2O antibody; UBE2O_HUMAN antibody; Ubiquitin carrier protein O antibody; Ubiquitin conjugating enzyme E2 O antibody; Ubiquitin conjugating enzyme E2 of 230 kDa antibody; ubiquitin conjugating enzyme E2O antibody; Ubiquitin protein ligase O antibody; Ubiquitin-conjugating enzyme E2 O antibody; Ubiquitin-conjugating enzyme E2 of 230 kDa antibody; Ubiquitin-conjugating enzyme E2-230K antibody; Ubiquitin-protein ligase O antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human UBE2O
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins. Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity. Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis. Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location. Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly.
  • 基因功能参考文献：
    1. UBE2O is a self-contained quality control factor that comprises substrate recognition and ubiquitin transfer activities within a single protein to efficiently target orphans of multiprotein complexes for degradation. PMID: 28774922
    2. UBE2O mediates c-Maf polyubiquitination and degradation, induces MM cell apoptosis, and suppresses myeloma tumor growth, which provides a novel insight in understanding myelomagenesis and UBE2O biology. PMID: 28673317
    3. UBE2O specifically targets AMPKalpha2 for ubiquitination and degradation, and thereby promotes activation of the mTOR-HIF1alpha pathway. PMID: 28162974
    4. UBE2O defines an atypical ubiquitin-signaling pathway that coordinates the function of BAP1. PMID: 24703950
    5. UBE2O negatively regulates TRAF6-mediated NF-kappaB activation by inhibiting TRAF6 polyubiquitination. PMID: 23381138
    6. monoubiquitinated SMAD6 impairs the binding affinity of non-modified SMAD6 to the BMP type I receptor. Moreover, UBE2O and SMAD6 cooperated in the regulation of BMP7-induced adipogenesis PMID: 23455153

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=Mainly localizes to the cytoplasm.
  • 蛋白家族：
    Ubiquitin-conjugating enzyme family
  • 组织特异性：
    Predominantly expressed in skeletal muscle and heart.
  • 数据库链接：

    HGNC: 29554

    OMIM: 617649

    KEGG: hsa:63893

    STRING: 9606.ENSP00000323687

    UniGene: Hs.16130