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UBE3C Antibody

  • 货号：
    CSB-PA621871LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) UBE3C Polyclonal antibody
  • Uniprot No.：
    Q15386
  • 基因名：
  • 别名：
    HectH2 antibody; KIAA0010 antibody; KIAA10 antibody; Ube3c antibody; UBE3C_HUMAN antibody; Ubiquitin protein isopeptide ligase (E3) antibody; Ubiquitin protein ligase E3C antibody; Ubiquitin-protein ligase E3C antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Ubiquitin-protein ligase E3C protein (310-377AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，UBE3C Antibody (CSB-PA621871LA01HU)，的标记方式是Non-conjugated。对于UBE3C Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA621871LB01HU UBE3C Antibody, HRP conjugated ELISA
    FITC CSB-PA621871LC01HU UBE3C Antibody, FITC conjugated
    Biotin CSB-PA621871LD01HU UBE3C Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.
  • 基因功能参考文献：
    1. miR-542-3p functioned as a tumor suppressor gene in regulating the epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma via targeting UBE3C. PMID: 28666208
    2. UBE3C promotes melanoma progression, possibly by inducing epithelial-mesenchymal transition in melanoma cells PMID: 26894856
    3. data reveal that high UBE3C expression contributes to glioma progression by ubiquitination and degradation of ANXA7, and thus presents a novel and promising target for glioma therapy. PMID: 26067607
    4. these observations suggest that UBE3C plays an important role in RCC development and progression, and UBE3C may be a novel target for prevention and treatment of ccRCC. PMID: 25658088
    5. UBE3C is a mutant candidate oncogene involved in tumor development and progression of hepatocellular carcinoma. PMID: 24425307
    6. knockdown renders cells more susceptible to the Hsp90 inhibitor 17-AAG, suggesting that UBE3C protects against the harmful accumulation of protein fragments arising from incompletely degraded proteasome substrates. PMID: 24158444
    7. Our findings provide evidence that variations in UBE3C are potent genetic markers of nasal polyps development in Korean asthmatics. PMID: 21881582
    8. negatively regulates type I interferon through ubiquitination of the transcription factors PMID: 21167755
    9. gene polymorphism is associated with the risk of Aspirin-intolerant asthma PMID: 20934631
    10. TIP120B is a specific substrate of KIAA10; both are highly expressed in human skeletal muscle, suggesting that KIAA10 may regulate TIP120B homeostasis specifically in this tissue. PMID: 12692129

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas.
  • 数据库链接：

    HGNC: 16803

    OMIM: 614454

    KEGG: hsa:9690

    STRING: 9606.ENSP00000309198

    UniGene: Hs.118351