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  4. UCK2 Antibody

UCK2 Antibody

  • 货号：
    CSB-PA025547GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BZX2
  • 基因名：
    UCK2
  • 别名：
    UCK2 antibody; UMPK antibody; Uridine-cytidine kinase 2 antibody; UCK 2 antibody; EC 2.7.1.48 antibody; Cytidine monophosphokinase 2 antibody; Testis-specific protein TSA903 antibody; Uridine monophosphokinase 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human UCK2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.
  • 基因功能参考文献：
    1. accumulation of RX-3117 nucleotides correlated with UCK2 expression. PMID: 27612203
    2. UCK1 and 2 are both expressed in several neuroblastoma cell lines, including four MYCN single copy cell lines and five MYCN amplified cell lines PMID: 27906629
    3. Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23. PMID: 23462292
    4. Increased intranuclear levels of UK may contribute to the metabolic build-up that is needed for Epstein-Barr virus nuclear protein EBNA-3-mediated B-cell blast transformation and rapid proliferation. PMID: 12199906
    5. UCK2 is responsible for phosphorylation and activation of the antitumor activity of 3'-ethynyl nucleosides 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine and 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)uridine. PMID: 15280220
    6. gene mapped to chromosome 1. PMID: 16484797
    7. B4GALT3, DAP3, RGS16, TMEM183A and UCK2--were significantly overexpressed in dup(1q)-positive ALLs compared with high hyperdiploid ALLs without dup(1q). PMID: 17613536
    8. The mechanism of phosphate transfer in UCK2 is shown to be concerted, and is accompanied by concerted proton transfer from the 5'-hydroxyl to a conserved active site aspartic acid that serves as a catalytic base PMID: 19532987

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  • 蛋白家族：
    Uridine kinase family
  • 组织特异性：
    According to PubMed:8812458; testis-specific. According to PubMed:11306702, placenta-specific.
  • 数据库链接：

    HGNC: 12562

    OMIM: 609329

    KEGG: hsa:7371

    STRING: 9606.ENSP00000356853

    UniGene: Hs.458360