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UFC1 Antibody

  • 货号：
    CSB-PA025558GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y3C8
  • 基因名：
    UFC1
  • 别名：
    CGI-126 antibody; HSPC155 antibody; Ubiquitin fold modifier conjugating enzyme 1 antibody; Ubiquitin-fold modifier-conjugating enzyme 1 antibody; UFC1 antibody; UFC1_HUMAN antibody; Ufm1 conjugating enzyme 1 antibody; Ufm1-conjugating enzyme 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human UFC1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    E1-like enzyme which specifically catalyzes the second step in ufmylation. Accepts the ubiquitin-like modifier UFM1 from the E1 enzyme UBA5 and forms an intermediate with UFM1 via a thioester linkage. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.
  • 基因功能参考文献：
    1. that UFC1 regulates survival of Osteoarthritis chondrocytes through physically association with miR-34a PMID: 27529373
    2. Autoantibodies binding to Ufc1 were found in 19 of 29 patients (66%) with active mycobacterial infections. PMID: 25213431
    3. Uba5 residues 364-404 were demonstrated to be necessary for the transthiolation of Ufm1 to Ufc1, and Uba5 381-404 was identified to be the minimal region for Ufc1 recognition PMID: 25084390
    4. UFC1 interact with the mRNA stabilizing protein HuR to increase levels of beta-catenin in hepatocellular carcinoma. PMID: 25449213
    5. NCAM140 interacts with ufc1 and its trafficking and endocytosis is upregulated in the presense of Ufm1. PMID: 24726913
    6. The structure of human Ufc1 was solved by using both NMR spectroscopy and X-ray crystallography PMID: 19101823
    7. Identification of a novel enzyme called UFC1 for Ufm1-conjugating enzyme 1. PMID: 15071506

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  • 蛋白家族：
    Ubiquitin-conjugating enzyme family, UFC1 subfamily
  • 数据库链接：

    HGNC: 26941

    OMIM: 610554

    KEGG: hsa:51506

    STRING: 9606.ENSP00000356982

    UniGene: Hs.301412