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UHMK1 Antibody

  • 货号：
    CSB-PA840554LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse brain tissue
      All lanes: UHMK1 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 47, 39, 40 kDa
      Observed band size: 47 kDa
    • Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA840554LA01HU at dilution of 1:100
    • Immunofluorescent analysis of PC-3 cells using CSB-PA840554LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) UHMK1 Polyclonal antibody
  • Uniprot No.：
    Q8TAS1
  • 基因名：
    UHMK1
  • 别名：
    DKFZp434C1613 antibody; FLJ23015 antibody; kinase interacting with leukemia-associated gene (stathmin) antibody; Kinase interacting with stathmin antibody; KIS antibody; KIS protein kinase antibody; KIST antibody; OTTHUMP00000029529 antibody; P-CIP2 antibody; Serine threonine protein kinase Kist antibody; Serine/threonine-protein kinase Kist antibody; U2AF homology motif (UHM) kinase 1 antibody; U2AF homology motif kinase 1 antibody; UHMK1 antibody; UHMK1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Serine/threonine-protein kinase Kist protein (183-385AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，UHMK1 Antibody (CSB-PA840554LA01HU)，的标记方式是Non-conjugated。对于UHMK1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA840554LB01HU UHMK1 Antibody, HRP conjugated ELISA
    FITC CSB-PA840554LC01HU UHMK1 Antibody, FITC conjugated
    Biotin CSB-PA840554LD01HU UHMK1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA.
  • 基因功能参考文献：
    1. UHMK1 plays a role in hematopoietic cell differentiation and suppression of autonomous clonal growth of leukemia cells. PMID: 29307747
    2. genome-wide association study identified the UHMK1 gene as a novel bone mineral density locus specific to East Asians. PMID: 27424934
    3. The contribution of UHMK1 gene in schizophrenia susceptibility, was explored. PMID: 21399567
    4. We identify the kinase responsible for S10 phosphorylation as human kinase interacting stathmin (hKIS) and show that it regulates cell cycle progression in response to mitogens. PMID: 12093740
    5. KIS gene was overexpressed in NF1-associated plexiform neurofibromas and malignant peripheral nerve sheath tumors (MPNSTs) as compared to dermal neurofibroma which suggests a possible implication of KIS in the genesis of NF1-associated tumors. PMID: 12782393
    6. These results provide preliminary evidence that the UHMK1 gene increases susceptibility to schizophrenia. Further confirmation in adequately powered samples is needed. PMID: 16978587
    7. KIS promoter is activated by serum-responsive GABP binding to Ets-binding sites which leads to KIS gene expression, cell migration, and cell cycle progression PMID: 17726090
    8. Results show that KIS is a direct transcriptional target of FoxM1. PMID: 17984092
    9. Overexpression of KIS protein kinase is associated with acute myelogenous leukemia, myelodysplastic syndrome and acute lymphoblastic leukemia PMID: 18384876
    10. The association between UHMK1 and schizophrenia is confirmed. PMID: 18414510
    11. KIS is expressed in neurons, and its encoded protein is localised to the nucleus and cytoplasm. No difference in KIS expression was found between schizophrenics and controls or in the lymphoblast cell lines. PMID: 19747464
    12. A follow up article showing further association between markers in UHMK1 and schizophrenia in a London based sample. Association replicated in an independent Scottish sample. PMID: 18414510
    13. Evidence indicating that UHMK1 may be a candidate susceptibility gene for Schizophrenia in the British population. UHMK1 is situated between previously implicated genes RGS4 and NOS1AP. PMID: 16978587

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family
  • 组织特异性：
    Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes.
  • 数据库链接：

    HGNC: 19683

    OMIM: 608849

    KEGG: hsa:127933

    STRING: 9606.ENSP00000420270

    UniGene: Hs.127310