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ULK3 Antibody

  • 货号：
    CSB-PA004389
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 293 cells using ULK3 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q6PHR2
  • 基因名：
    ULK3
  • 别名：
    DKFZP434C131 antibody; FLJ90566 antibody; Serine/threonine-protein kinase ULK3 antibody; Ulk3 antibody; ULK3_HUMAN antibody; unc 51 like kinase 3 (C. elegans) antibody; Unc-51-like kinase 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ULK3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
  • 基因功能参考文献：
    1. Increased ULK3 also induces autophagy, which is unlinked from GLI and CAF activation. ULK3 upregulation occurs in the CAFs of several tumor types, and ULK3 silencing suppresses the tumor-enhancing properties of these cells. PMID: 28877478
    2. Structural and biochemical studies reveal an unusually tight interaction between ULK3 and IST1, an ESCRT-III subunit required for cytokinetic abscission. PMID: 26011858
    3. First named and identified as protein kinase of the ULK family PMID: 12471243
    4. Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway. PMID: 20643644
    5. serine/threonine kinase ULK3 is involved in the SHH pathway as a positive regulator of GLI proteins PMID: 19878745

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  • 亚细胞定位：
    Cytoplasm. Note=Localizes to pre-autophagosomal structure during cellular senescence.
  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family, APG1/unc-51/ULK1 subfamily
  • 组织特异性：
    Widely expressed. Highest levels observed in fetal brain. In adult tissues, high levels in brain, liver and kidney, moderate levels in testis and adrenal gland and low levels in heart, lung, stomach, thymus, prostate and placenta. In the brain, highest ex
  • 数据库链接：

    HGNC: 19703

    OMIM: 613472

    KEGG: hsa:25989

    STRING: 9606.ENSP00000400312

    UniGene: Hs.513034