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UNC13A Antibody

  • 货号：
    CSB-PA025621GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9UPW8
  • 基因名：
  • 别名：
    UNC13A antibody; KIAA1032 antibody; Protein unc-13 homolog A antibody; Munc13-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human UNC13A
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    0.1M NaHCO3,0.1M Glycine, 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release. Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes.
  • 基因功能参考文献：
    1. This study demonstrated that the population specific rare variants of UNC13A may modulate survival in ALS in United kingdom. PMID: 27584932
    2. Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder PMID: 28192369
    3. UNC13A rs12608932 is a risk factor for ALS and a modifying factor for survival and disease progression rate in a Spanish cohort. PMID: 26162714
    4. Munc13-1, on account of its role in both insulin and neurotransmitter exocytosis and through its binding properties, may be an important factor contributing to the development or progression of diabetic neuropathy. PMID: 23830992
    5. UNC13A provides a novel link between amyotrophic lateral sclerosis and frontotemporal dementia and identifies changes in neurotransmitter release and synaptic function as a converging mechanism in the pathogenesis of ALS and FTD-TDP. PMID: 24931836
    6. CAPS1 binds to the full-length of cytoplasmic syntaxin-1 with preference to its "open" conformation, whereas Munc13-1 binds to the first 80 N-terminal residues of syntaxin-1. PMID: 23801330
    7. This study demonistrated that UNC13A influences survival in Italian amyotrophic lateral sclerosis patients. PMID: 22921269
    8. Our results further corroborate the role of UNC13A in amyotrophic lateral sclerosis pathogenesis. PMID: 22118904
    9. Results do not provide evidence of an association between a variant in the UNC13A gene and susceptibility to sporadic Amyotrophic lateral sclerosis in a French homogeneous population. PMID: 20385924
    10. rs12608932 Single Nucleotide Polymorphism is located at 19p13.3 and maps to a haplotype block within the boundaries of UNC13A, which regulates the release of neurotransmitters such as glutamate at neuromuscular synapses. PMID: 19734901

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  • 亚细胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein. Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein. Cell junction, synapse, presynaptic active zone.
  • 蛋白家族：
    Unc-13 family
  • 组织特异性：
    Expressed in pancreatic islet cells. Expressed in melanocytes.
  • 数据库链接：

    HGNC: 23150

    OMIM: 609894

    KEGG: hsa:23025

    STRING: 9606.ENSP00000429562

    UniGene: Hs.164502