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UNC50 Antibody

  • 货号：
    CSB-PA687496LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: UNC50 antibody at 0.2µg/ml + 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 31 kDa
      Observed band size: 31 kDa
    • Immunofluorescent analysis of A549 cells using CSB-PA687496LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) UNC50 Polyclonal antibody
  • Uniprot No.：
    Q53HI1
  • 基因名：
    UNC50
  • 别名：
    UNC50; UNCL; HSD-23; HSD23; Protein unc-50 homolog; Periodontal ligament-specific protein 22; PDLs22; Protein GMH1 homolog; hGMH1; Uncoordinated-like protein
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Protein unc-50 homolog protein (15-82AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，UNC50 Antibody (CSB-PA687496LA01HU)，的标记方式是Non-conjugated。对于UNC50 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA687496LB01HU UNC50 Antibody, HRP conjugated ELISA
    FITC CSB-PA687496LC01HU UNC50 Antibody, FITC conjugated
    Biotin CSB-PA687496LD01HU UNC50 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the cell surface expression of neuronal nicotinic receptors. Binds RNA.
  • 基因功能参考文献：
    1. Data indicate that biallelic mutation in the UNC50 gene underlies AMC through a probable loss of AChR expression at the neuromuscular junction which is essential for the cholinergic transmission during human muscle development. PMID: 29016857
    2. depletion of UNC50 blocked early endosome-to-Golgi trafficking and induced lysosomal degradation of STx2. UNC50 acted by recruiting GBF1, an ADP ribosylation factor-guanine nucleotide exchange factor (ARF-GEF), to the Golgi. PMID: 28883040
    3. UNC50 may plays some roles in HCC progression by affecting the EGFR pathway PMID: 25738771
    4. UNCL plays important roles in the development, differentiation, and maintenance of periodontal tissues and in the mechanotransduction of periodontal ligament fibroblasts. PMID: 17004066
  • 亚细胞定位：
    Nucleus inner membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Unc-50 family
  • 组织特异性：
    Present in periodontal ligament fibroblasts (at protein level).
  • 数据库链接：

    HGNC: 16046

    OMIM: 617826

    KEGG: hsa:25972

    STRING: 9606.ENSP00000350409

    UniGene: Hs.13370