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UNC80 Antibody

  • 货号：
    CSB-PA854025LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescent analysis of HepG2 cells using CSB-PA854025LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in Recombinant protein
      All lanes: UNC80 antibody at 3.5µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 59 kDa
      Observed band size: 59 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) UNC80 Polyclonal antibody
  • Uniprot No.：
    Q8N2C7
  • 基因名：
    UNC80
  • 别名：
    C2orf21 antibody; Protein unc-80 homolog antibody; UNC 80 antibody; Unc 80 homolog (C. elegans) antibody; Unc80 antibody; UNC80_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Protein unc-80 homolog protein (124-388AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，UNC80 Antibody (CSB-PA854025LA01HU)，的标记方式是Non-conjugated。对于UNC80 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA854025LB01HU UNC80 Antibody, HRP conjugated ELISA
    FITC CSB-PA854025LC01HU UNC80 Antibody, FITC conjugated
    Biotin CSB-PA854025LD01HU UNC80 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the NALCN sodium channel complex, required for channel regulation. This complex is a cation channel activated by neuropeptides substance P, neurotensin, and extracellular calcium that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current. UNC80 is essential for NALCN sensitivity to extracellular calcium.
  • 基因功能参考文献：
    1. UNC80 variant is associated with neurodevelopmental diseases. PMID: 30167850
    2. Biallelic UNC80 mutations caused infantile hypotonia with psychomotor retardation and characteristic facies 2 in two Chinese patients with variable phenotypes PMID: 29572195
    3. UNC80 bridges between UNC79 and the cation channel NALCN. PMID: 26545877
    4. Further supporting the UNC80 mutations as causative of these siblings' disorder, biallelic mutations in UNC80 have recently been described among individuals with an overlapping phenotype. This report expands the disease spectrum associated with UNC80 mutations PMID: 27513830
    5. findings demonstrate the fundamental significance of UNC80 and basal ionic conductance to human health PMID: 26708751
    6. UNC80 encodes a large protein that is necessary for the stability and function of NALCN and for bridging NALCN to UNC79 to form a functional complex PMID: 26708753
    7. UNC80 functions as a scaffold for Src kinases in NALCN channel function. PMID: 19535918

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  • 相关疾病：
    Hypotonia, infantile, with psychomotor retardation and characteristic facies 2 (IHPRF2)
  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Unc-80 family
  • 组织特异性：
    Moderately expressed in fetal brain, spinal cord, skeletal muscle, thymus, spleen, fetal liver, small intestine, colon, kidney and uterus. Highly expressed in adrenal gland, prostate and testis, as well as in brain and cerebellum.
  • 数据库链接：

    HGNC: 26582

    OMIM: 612636

    KEGG: hsa:285175

    STRING: 9606.ENSP00000391088

    UniGene: Hs.396201