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UPF2 Antibody

  • 货号：
    CSB-PA867186DSR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA867186DSR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) UPF2 Polyclonal antibody
  • Uniprot No.：
    Q9HAU5
  • 基因名：
    UPF2
  • 别名：
    DKFZp434D222 antibody; hUpf2 antibody; KIAA1408 antibody; MGC138834 antibody; MGC138835 antibody; Nonsense mRNA reducing factor 2 antibody; Regulator of nonsense transcripts 2 antibody; RENT2 antibody; RENT2_HUMAN antibody; Smg 3 antibody; Smg 3 homolog nonsense mediated mRNA decay factor antibody; Up-frameshift suppressor 2 homolog antibody; UPF2 antibody; UPF2 regulator of nonsense transcripts homolog antibody; UROC1 antibody; Urocanate hydratase antibody; Yeast Upf2p homolog antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Regulator of nonsense transcripts 2 protein (1153-1272AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.
  • 基因功能参考文献：
    1. UPF2 binds the FRB domain of SMG1, a region that regulates the related mTOR kinase. PMID: 25002321
    2. UPF2 MIF4G-1 and MIF4G-2 domains appear to have a crucial scaffolding role, while the MIF4G-3 domain is the key module required for triggering nonsense-mediated decay. PMID: 24271394
    3. Data show that upon binding to Upf2, the regulatory CH domain of Upf1 undergoes a large conformational change, causing the catalytic helicase domain to bind RNA less extensively and triggering its helicase activity. PMID: 21419344
    4. The s propose that the bipartite mode of UPF2 binding to UPF1 brings the ribosome and the exon junction complex in close proximity by forming a tight complex after an initial weak encounter with either element. PMID: 19556969
    5. The complex between the interacting domains of human UPF2 and UPF3b at a 1.95 A resolution. PMID: 15004547
    6. During nonsense-mediated mRNA decay, CBP80 interacts with Upf1 and promotes the interaction of Upf1 with Upf2 but not with Stau1. PMID: 16186820
    7. UPF2-silenced HeLa cells were impaired in their ability to recognize ectopically expressed aberrant premature termination codon transcripts PMID: 16449641
    8. The Upf complex communicates with the exon-junction complex and triggers nonsense-mediated decay in the cytoplasm. PMID: 17803942
    9. UPF2 and UPF3b cooperatively stimulate both ATPase and RNA helicase activities of UPF1. PMID: 18066079

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  • 亚细胞定位：
    Cytoplasm, perinuclear region.
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 17854

    OMIM: 605529

    KEGG: hsa:26019

    STRING: 9606.ENSP00000348708

    UniGene: Hs.370689