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  4. URM1 Antibody

URM1 Antibody

  • 货号：
    CSB-PA025676GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BTM9
  • 基因名：
    URM1
  • 别名：
    2900073H19Rik antibody; C9orf74 antibody; Chromosome 9 open reading frame 74 antibody; MGC2668 antibody; RGD1306599 antibody; RP11 339B21.4 antibody; RP23-443G7.1 antibody; Ubiquitin related modifier 1 antibody; Ubiquitin related modifier 1 homolog antibody; Ubiquitin-related modifier 1 homolog antibody; Urm 1 antibody; URM1 antibody; URM1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human URM1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
  • 基因功能参考文献：
    1. ubiquitin-like Urm1.Uba4 systems are conserved and exchangeable between human and yeast cells PMID: 25747390
    2. Urm1 has a conserved dual role by integrating the functions of prokaryotic sulfur carriers with those of eukaryotic protein modifiers of the Ub family PMID: 21209336
    3. observations suggest that Urm1 activation is more similar to that of a prokaryotic sulfur carrier protein than that of a ubiquitin-like protein PMID: 21245332
    4. The UBA4-URM1 system represents the evolutionary link between protein conjugation and protein modification by sulfur carrier proteins. PMID: 18491921
    5. Urm1 is activated by an unusual mechanism to yield a thiocarboxylate intermediate that serves as sulfur donor in tRNA thiolation reactions PMID: 19017811

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    URM1 family
  • 数据库链接：

    HGNC: 28378

    OMIM: 612693

    KEGG: hsa:81605

    STRING: 9606.ENSP00000412922

    UniGene: Hs.495229