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UROD Antibody

  • 货号：
    CSB-PA025678GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P06132
  • 基因名：
    UROD
  • 别名：
    DCUP_HUMAN antibody; PCT antibody; UPD antibody; URO D antibody; URO-D antibody; urod antibody; Uroporphyrinogen decarboxylase antibody; Uroporphyrinogen III decarboxylase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human UROD
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  • 基因功能参考文献：
    1. a new mutation in the UROD gene in Egyptian patients with Hepatoerythropoietic porphyria, is reported. PMID: 26789143
    2. a new insight in the conformational changes occurred in the mutant structures of UROD protein. PMID: 24777812
    3. Data suggest that the traditional Chinese medicine (TCM) candidate potential three-in-one inhibitors for three drug target proteins epidermal growth factor receptor (EGFR), Her2, and uroporphyrinogen decarboxylase (UROD) against head and neck cancer. PMID: 23140436
    4. Expression of the D306Y mutation results in an insoluble recombinant protein. G318R and K297N have little effect on the structure or activity of recombinant URO-D, but the proteins display reduced stability in vitro. PMID: 19656450
    5. Among seventeen F-PCT patients, sixteen UROD mutations were identified. PMID: 23545314
    6. analysis of uroporphyrinogen decarboxylase as a potential target for specific components of traditional Chinese medicine PMID: 23209648
    7. Mutations in UROD gene is associated with familial porphyria cutanea tarda. PMID: 22382040
    8. Hepatoerythropoietic porphyria and familial porphyria cutanea tarda G281E mutation in the uroporphyrinogen decarboxylase gene PMID: 21079081
    9. function of Arg37 in uroporphyrinogen III decarboxylase PMID: 20553007
    10. description of 3 siblings with hepatoerythropoietic porphyria; sequencing of the UROD gene revealed compound heterozygosity for a novel missense mutation, V166A, and a complex deletion/insertion, 645del1053ins10 PMID: 20479301
    11. Sequence deletions in uroporphyrinogen decarboxylase is associated with Porphyria Cutanea Tarda. PMID: 15046048
    12. we identified eight mutations in 18 previously unclassified porphyria cutanea tarda families PMID: 15186324
    13. Sequencing of the hydroxymethylbilane synthase and uroporphyrinogen decarboxylase genes confirmed the relatively rare diagnosis of dual porphyria, and revealed a novel uroporphyrinogen decarboxylase mutation PMID: 16390615
    14. There is a high degree of molecular heterogeneity of familial porphyria cutanea tarda in Spain and molecular genetic analysis is useful in distinguish between F-PCT and sporadic PCT. PMID: 17627795
    15. role of UROD mutations as a strong risk factor for porphyria cutanea tarda even in areas where environmental factors (hepatitis C virus) have been shown to be highly associated with the disease PMID: 19419417

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  • 相关疾病：
    Familial porphyria cutanea tarda (FPCT); Hepatoerythropoietic porphyria (HEP)
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Uroporphyrinogen decarboxylase family
  • 数据库链接：

    HGNC: 12591

    OMIM: 176100

    KEGG: hsa:7389

    STRING: 9606.ENSP00000246337

    UniGene: Hs.78601