USP13 Antibody
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货号:CSB-PA070185
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规格:¥880
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其他:
产品详情
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Uniprot No.:Q92995
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基因名:
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别名:Deubiquitinating enzyme 13 antibody; Isopeptidase T 3 antibody; Isopeptidase T-3 antibody; Isopeptidase T3 antibody; ISOT 3 antibody; ISOT-3 antibody; ISOT3 antibody; Ubiquitin carboxyl terminal hydrolase 13 antibody; Ubiquitin carboxyl-terminal hydrolase 13 antibody; Ubiquitin specific peptidase 13 (isopeptidase T3) antibody; Ubiquitin specific peptidase 13 antibody; Ubiquitin specific processing protease 13 antibody; Ubiquitin specific protease 13 antibody; Ubiquitin thioesterase 13 antibody; Ubiquitin thiolesterase 13 antibody; Ubiquitin-specific-processing protease 13 antibody; UBP13 antibody; UBP13_HUMAN antibody; USP 13 antibody; USP13 antibody
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宿主:Rabbit
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反应种属:Human,Mouse
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免疫原:Synthesized peptide derived from the C-terminal region of Human USP13.
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
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抗体亚型:IgG
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纯化方式:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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产品提供形式:Liquid
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应用范围:WB, IHC, ELISA
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推荐稀释比:
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:40000 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data.
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基因功能参考文献:
- USP13 is a regulator of DNA repair.USP13 regulates RAP80-BRCA1 complex foci formation.The role of USP13 in the neoplasm drug resistance. PMID: 28569838
- These results reveal an important metabolism-centric role of USP13, which may lead to potential therapeutics targeting USP13 in ovarian cancers. PMID: 27892457
- in the samples of 293T cell lines after the overexpression of USP13 and USP13 C345S, vinculin exhibited an increased expression, suggesting that it may be a candidate substrate of USP13. PMID: 28498477
- Deubiquitinating enzyme 13 (USP13) regulates myeloid cell leukemia sequence 1 protein (MCL1) stability in lung and ovarian cancer cells. PMID: 29335437
- our results demonstrate that AR can promote melanoma metastasis via altering the miRNA-539-3p/USP13/MITF/AXL signal and targeting this newly identified signal with AR degradation enhancer ASC-J9 may help us to better suppress the melanoma metastasis. PMID: 27869170
- USP13 and FBXL14 play opposing roles in the regulation of glioma stem cells (GSCs) through reversible ubiquitination of c-Myc. PMID: 27923907
- Down-regulation of USP13 mediates PTEN protein loss and fibroblast phenotypic change, and thereby plays a crucial role in idiopathic pulmonary fibrosis pathogenesis. PMID: 26453058
- USP13 is a tumour-suppressing protein that functions through deubiquitylation and stabilization of PTEN. PMID: 24270891
- to our knowledge, USP13 is the first deubiquitinating enzymes identified to modulate STAT1 and play a role in the antiviral activity of IFN against DEN-2 replication. PMID: 23940278
- USP10 mediates the deubiquitination of p53, regulating deubiquitination activity of USP10 and USP13 by Beclin1 provides a mechanism for Beclin1 to control the levels of p53. PMID: 21962518
- Through deubiquitination, USP13 stabilizes and upregulates MITF protein levels. PMID: 21811243
- study identifies a new layer of Siah2 regulation mediated by USP13 binding to ubiquitinated Siah2 protein with a concomitant inhibitory effect on its activity under normoxia PMID: 21659512
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蛋白家族:Peptidase C19 family
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组织特异性:Highly expressed in ovary and testes.
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数据库链接:
HGNC: 12611
OMIM: 603591
KEGG: hsa:8975
STRING: 9606.ENSP00000263966
UniGene: Hs.175322
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