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USP25 Antibody

  • 货号：
    CSB-PA025715GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9UHP3
  • 基因名：
  • 别名：
    Deubiquitinating enzyme 25 antibody; Ubiquitin carboxyl-terminal hydrolase 25 antibody; Ubiquitin specific peptidase 25 antibody; ubiquitin specific protease 25 antibody; ubiquitin specific protease USP25 antibody; Ubiquitin thiolesterase 25 antibody; Ubiquitin-specific-processing protease 25 antibody; UBP25_HUMAN antibody; USP on chromosome 21 antibody; USP21 antibody; USP25 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human USP25
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains.; The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.
  • 基因功能参考文献：
    1. Smurf1 overexpression decreases USP25 protein turnover, and the E3 ligase enzymatic activity of Smurf1 is required for USP25 degradation. PMID: 29518389
    2. USP25 directly interacted with tankyrases to promote their deubiquitination and stabilization and demonstrated that USP25 deficiency could promote the degradation of tankyrases and consequent stabilization of Axin to antagonize Wnt signaling PMID: 28619731
    3. Results suggest inhibition of Usp25's catalytic activity upon the non-covalent binding of SUMO2 to the Usp25 SUMO-interacting motif, and found that SUMO2 can competitively block the interaction between the Usp25 ubiquitin-binding region and its ubiquitin substrates. PMID: 28538147
    4. We detected SNPs at USP25 with associations of genome-wide significance for Inflammatory Bowel Disease. PMID: 27693347
    5. REM Sleep Behavior Disorder patients with homozygous USP25 rs2823357 progressed to synucleinopathies faster than others. PMID: 25929833
    6. Findings suggest that ubiquitin-specific protease 25 (USP25) as a VRK2 substrate that acts on TRiC deubiquitination. PMID: 25755282
    7. These findings indicate that miR-200c exerts tumor-suppressive effects for NSCLC through the suppression of USP25 expression and suggests a new therapeutic application of miR-200c in the treatment of NSCLC. PMID: 24997798
    8. USP25 is a novel deubiquitinating enzyme negatively regulating virus-induced interferon-beta production. PMID: 24260525
    9. a model where USP25 counteracts ubiquitination of ERAD substrates by the ubiquitin ligase HRD1, rescuing them from degradation by the proteasome. PMID: 22590560
    10. Studies indicate that DUBs recycle ubiquitin by processing polyubiquitin chains to generate free ubiquitin, and can be regulated by ubiquitination or phosphorylation. PMID: 21480003
    11. the second SH2 domain of SYK physically interacts with a tyrosine-rich, C-terminal region of USP25 independently of tyrosine phosphorylation PMID: 19909739
    12. characterization of alternatively spliced products and tissue-specific isoforms PMID: 11597335
    13. downregulation of USP25 gene in human lung cancer PMID: 18523997
    14. Seven amino acids in the SIM of USP25 are sufficient for SUMO2/3-specific binding and conjugation PMID: 18538659
    15. Data show that USP25m is regulated through alternative conjugation of ubiquitin (activating) or SUMO (inhibiting) to the same lysine residue (K99), which may promote the interaction with distinct intramolecular regulatory domains. PMID: 19440361

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  • 亚细胞定位：
    Cytoplasm.; [Isoform USP25m]: Cytoplasm. Nucleus.
  • 蛋白家族：
    Peptidase C19 family
  • 组织特异性：
    Isoform USP25a is found in most adult and fetal tissues; expression is moderately high in testis, pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, but very low in peripheral blood, colon, small intestine, ovary, prostate, thymus and
  • 数据库链接：

    HGNC: 12624

    OMIM: 604736

    KEGG: hsa:29761

    STRING: 9606.ENSP00000285679

    UniGene: Hs.743994