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USP3 Antibody

  • 货号：
    CSB-PA896756LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA896756LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA896756LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) USP3 Polyclonal antibody
  • Uniprot No.：
    Q9Y6I4
  • 基因名：
  • 别名：
    Deubiquitinating enzyme 3 antibody; EC 3.1.2.15 antibody; SIH003 antibody; Ubiquitin carboxyl-terminal hydrolase 3 antibody; Ubiquitin specific peptidase 3 antibody; Ubiquitin specific processing protease 3 antibody; Ubiquitin Specific Protease 3 antibody; Ubiquitin thioesterase 3 antibody; Ubiquitin thiolesterase 3 antibody; Ubiquitin-specific-processing protease 3 antibody; UBP antibody; UBP3_HUMAN antibody; Usp3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Ubiquitin carboxyl-terminal hydrolase 3 protein (201-500AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，USP3 Antibody (CSB-PA896756LA01HU)，的标记方式是Non-conjugated。对于USP3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA896756LB01HU USP3 Antibody, HRP conjugated ELISA
    FITC CSB-PA896756LC01HU USP3 Antibody, FITC conjugated
    Biotin CSB-PA896756LD01HU USP3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.
  • 基因功能参考文献：
    1. Data found that USP3 was overexpressed in gastric cancer (GC) tissues and cells. USP3 overexpression can be a useful biomarker for predicting the outcomes of GC patients. Moreover, USP3 was shown to influence cell proliferation by regulating cell cycle control and metastasis-related proteins. In vivo experiments showed that USP3 promoted GC tumor growth and metastasis. PMID: 30168892
    2. Depletion of USP3 lead to accelerated degradation of p53 in normal cells thereby enhanced cell proliferation and transformation. Reconstitution of wildtype USP3, but not the USP3 C168S mutant, restored the stability of p53 protein and inhibited cell proliferation and transformation. PMID: 28807825
    3. Taken together, the results suggested that USP3 is a negative regulator of ubiquitination signaling, counteracting RNF168- and RNF8-mediated ubiquitination. PMID: 24196443
    4. the role of UCP3 gene in functional status and survival at old age. PMID: 22743239
    5. Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20445134
    6. Ubiquitin-specific protease 3 (USP3) is a deubiquitinating enzyme for monoubiquitinated histones H2A and H2B; USP3 dynamically associates with chromatin and deubiquitinates H2A/H2B in vivo. PMID: 17980597

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  • 亚细胞定位：
    Nucleus. Note=Localizes preferentially with monoubiquitinated H2A to chromatin.
  • 蛋白家族：
    Peptidase C19 family, USP3 subfamily
  • 组织特异性：
    Expressed in all tissues examined, with strongest expression in pancreas.
  • 数据库链接：

    HGNC: 12626

    OMIM: 604728

    KEGG: hsa:9960

    STRING: 9606.ENSP00000369681

    UniGene: Hs.458499