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USP44 Antibody

  • 货号：
    CSB-PA060300
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 293T cells using USP44 Polyclonal Antibody
    • Western blot analysis of mouse-kidney lysis using USP44 antibody.
  • 其他：

产品详情

  • Uniprot No.：
    Q9H0E7
  • 基因名：
    USP44
  • 别名：
    Deubiquitinating enzyme 44 antibody; E430004F17Rik antibody; Ubiquitin carboxyl-terminal hydrolase 44 antibody; ubiquitin specific peptidase 44 antibody; Ubiquitin thiolesterase 44 antibody; Ubiquitin-specific-processing protease 44 antibody; UBP44_HUMAN antibody; USP44 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human USP44.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination.
  • 基因功能参考文献：
    1. These data imply a complex picture where regulating factors such as OCT4 may interact with other epigenetic mechanisms to regulate USP44 expression in pluripotent stem cells and testes. PMID: 28520534
    2. USP44 protein was widely expressed in most of the tumor samples and no clear association could be established between its expression and DNA ploidy status or tumor size PMID: 28492742
    3. In summary, we report that the combination of USP44 expression and DNA ploidy status might serve as an independent prognostic marker in gastric cancer. PMID: 28544703
    4. USP44 contributes to N-CoR functions in regulating gene expression and is required for efficient invasiveness of triple-negative breast cancer cells. PMID: 27880911
    5. USP44+ Cancer Stem Cell Subclones Contribute to Breast Cancer Aggressiveness by Promoting Vasculogenic Mimicry PMID: 26232424
    6. USP44 is epigenetically inactivated in colorectal adenomas, but this alone is not sufficient to cause aneuploidy in colorectal neoplasia. PMID: 24837038
    7. findings implicate USP44 in negative regulation of the RNF8/RNF168 pathway PMID: 23615962
    8. Data identify Cdc20, USP44, and Wee1 as relevant Fcp1 targets. PMID: 22692537
    9. These data are consistent with an important role for USP44 in regulating Cdc20-APC/C activity and suggest that high levels of this enzyme may contribute to the pathogenesis of T-cell leukemias. PMID: 21853124
    10. a dynamic balance of ubiquitination by the APC and deubiquitination by USP44 contributes to the generation of the switch-like transition controlling anaphase entry PMID: 17443180

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Peptidase C19 family, USP44 subfamily
  • 组织特异性：
    Expressed in testis. Expressed at high levels in T-cell acute lymphoblastic leukemia.
  • 数据库链接：

    HGNC: 20064

    OMIM: 610993

    KEGG: hsa:84101

    STRING: 9606.ENSP00000258499

    UniGene: Hs.646421