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VIPAS39 Antibody

  • 货号：
    CSB-PA888005LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: VIPAS39 antibody at 12µg/ml
      Lane 1: HepG2 whole cell lysate
      Lane 2: A431 whole cell lysate
      Lane 3: 293T whole cell lysate
      Lane 4: Mouse kidney tissue
      Lane 5: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 58, 52 kDa
      Observed band size: 58 kDa
    • Immunofluorescence staining of Hela cells with CSB-PA888005LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) VIPAS39 Polyclonal antibody
  • Uniprot No.：
    Q9H9C1
  • 基因名：
    VIPAS39
  • 别名：
    Apical basolateral polarity regulator antibody; FLJ12707 antibody; hSPE-39 antibody; Protein spe-39 homolog antibody; SPE 39 antibody; SPE 39 protein antibody; SPE39 antibody; Uncharacterized protein C14orf133 antibody; vipar antibody; VIPAR_HUMAN antibody; VPS16B antibody; VPS33B interacting protein antibody; VPS33B interacting protein apical basolateral polarity regulator antibody; VPS33B interacting protein involved in polarity and apical protein restriction antibody; VPS33B-interacting protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Spermatogenesis-defective protein 39 homolog protein (1-493AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，VIPAS39 Antibody (CSB-PA888005LA01HU)，的标记方式是Non-conjugated。对于VIPAS39 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA888005LB01HU VIPAS39 Antibody, HRP conjugated ELISA
    FITC CSB-PA888005LC01HU VIPAS39 Antibody, FITC conjugated
    Biotin CSB-PA888005LD01HU VIPAS39 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity. May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be independent of VPS33B. May play a role in vesicular trafficking during spermatogenesis. May be involved in direct or indirect transcriptional regulation of E-cadherin.
  • 基因功能参考文献：
    1. A likely causal mutation was identified in the majority (61%), spanning many genes including ones that have only rarely been reported to cause cholestatic liver disease, e.g. TJP2 and VIPAS39 PMID: 28039895
    2. Genetic studies showed a homozygous mutation in the VIPAS39 gene. Making the definite diagnosis of the syndrome is important, while increased risk of mutation in other siblings highlights the importance of prenatal diagnosis. PMID: 26808426
    3. Our data suggest that the ARC syndrome may result through impaired VIPAS39/SPE-39 and Vps33b-dependent endosomal maturation or fusion. PMID: 23918659
    4. VPS16B, similar to its binding partner VPS33B, is essential for megakaryocyte and platelet alpha-granule biogenesis. PMID: 23002115
    5. SPE-39 has an inhibitory effect due to tyrosine phosphorylation and ubiquitination on the function of Vps33B in the EGF-stimulated cells PMID: 22677173
    6. SPE-39 homologues are present in RAB5-, RAB7-, and RAB11-positive endosomes where they play a conserved role in lysosomal delivery and probably function via their interaction with the core HOPS complex. PMID: 19109425

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  • 相关疾病：
    Arthrogryposis, renal dysfunction and cholestasis syndrome 2 (ARCS2)
  • 亚细胞定位：
    Cytoplasm. Cytoplasmic vesicle. Early endosome. Recycling endosome. Late endosome. Note=Colocalizes in clusters with VPS33B at cytoplasmic organelles (PubMed:19109425).
  • 蛋白家族：
    SPE39 family
  • 数据库链接：

    HGNC: 20347

    OMIM: 613401

    KEGG: hsa:63894

    STRING: 9606.ENSP00000339122

    UniGene: Hs.16157