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VKORC1L1 Antibody

  • 货号：
    CSB-PA818673LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA818673LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human stomach tissue using CSB-PA818673LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) VKORC1L1 Polyclonal antibody
  • Uniprot No.：
    Q8N0U8
  • 基因名：
    VKORC1L1
  • 别名：
    VKORC1L1; Vitamin K epoxide reductase complex subunit 1-like protein 1; VKORC1-like protein 1
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Vitamin K epoxide reductase complex subunit 1-like protein 1 protein (38-91AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，VKORC1L1 Antibody (CSB-PA818673LA01HU)，的标记方式是Non-conjugated。对于VKORC1L1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA818673LB01HU VKORC1L1 Antibody, HRP conjugated ELISA
    FITC CSB-PA818673LC01HU VKORC1L1 Antibody, FITC conjugated
    Biotin CSB-PA818673LD01HU VKORC1L1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins.
  • 基因功能参考文献：
    1. This study showed that polymorphisms of EPHX1 and VKORC1L1 could be determinants of stable warfarin doses. PMID: 29054760
    2. a concerted action of the four conserved cysteines of VKORC1L1 for active site regeneration PMID: 24532791
    3. VKORC1L1 is responsible for driving vitamin K-mediated intracellular antioxidation pathways critical to cell survival. PMID: 21367861
    4. VKORC1L1 does not affect the variability of warfarin dose requirement in a Japanese patient population PMID: 17996924
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    VKOR family
  • 数据库链接：

    HGNC: 21492

    OMIM: 608838

    KEGG: hsa:154807

    STRING: 9606.ENSP00000353998

    UniGene: Hs.427232