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VPS33A Antibody

  • 货号：
    CSB-PA850260LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA850260LA01HU at dilution of 1:100
    • Immunofluorescent analysis of U251 cells using CSB-PA850260LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) VPS33A Polyclonal antibody
  • Uniprot No.：
    Q96AX1
  • 基因名：
    VPS33A
  • 别名：
    VPS33AVacuolar protein sorting-associated protein 33A antibody; hVPS33A antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Vacuolar protein sorting-associated protein 33A protein (1-300AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，VPS33A Antibody (CSB-PA850260LA01HU)，的标记方式是Non-conjugated。对于VPS33A Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA850260LB01HU VPS33A Antibody, HRP conjugated ELISA
    FITC CSB-PA850260LC01HU VPS33A Antibody, FITC conjugated
    Biotin CSB-PA850260LD01HU VPS33A Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39. The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG.
  • 基因功能参考文献：
    1. Mutations in VPS33A is associated with mucopolysaccharidosis with severe systemic symptoms. PMID: 28013294
    2. The clinical phenotype and genetic studies support the suggestion that the siblings most probably have a novel disease very likely caused by a VPS33A gene defect. PMID: 27547915
    3. association of VPS33A with HOPS via its interaction with VPS16 is required for both endosome- and autophagosome-lysosome fusion PMID: 25783203
    4. Melanoma cells depleted of vacuolar protein sorting 33A protein have increased nuclear localization of cis-diaminedichloroplatinum II, increased nuclear DNA damage by platination, and increased apoptosis, resulting in increased treatment sensitivity. PMID: 22203954
    5. VPS33A is mutated in Hermansky-Pudlak syndrome and may have a role in melanogenesis PMID: 12538872
    6. A and B classes reflect the evolution of organelle/tissue-specific functions PMID: 15790593

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  • 相关疾病：
    Mucopolysaccharidosis-plus syndrome (MPSPS)
  • 亚细胞定位：
    Cytoplasmic vesicle. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle, clathrin-coated vesicle.
  • 蛋白家族：
    STXBP/unc-18/SEC1 family
  • 数据库链接：

    HGNC: 18179

    OMIM: 610034

    KEGG: hsa:65082

    STRING: 9606.ENSP00000267199

    UniGene: Hs.487883