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VPS45 Antibody

  • 货号：
    CSB-PA882092LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: VPS45 antibody at 3μg/ml
      Lane 1: Mouse brain tissue
      Lane 2: U87 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 66, 62 kDa
      Observed band size: 41 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA882092LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) VPS45 Polyclonal antibody
  • Uniprot No.：
    Q9NRW7
  • 基因名：
  • 别名：
    h-VPS45 antibody; H1 antibody; H1VPS45 antibody; HGNC:14579 antibody; hlVps45 antibody; Leucocyte vacuolar protein sorting 45 antibody; OTTHUMP00000014482 antibody; Vacuolar protein sorting 45 homolog (S. cerevisiae) antibody; Vacuolar protein sorting 45A (yeast homolog) antibody; Vacuolar protein sorting 45A antibody; Vacuolar protein sorting 45B (yeast) antibody; Vacuolar protein sorting-associated protein 45 antibody; Vps45 antibody; VPS45_HUMAN antibody; VPS45A antibody; VPS45B antibody; VPS54A antibody; VSP45 antibody; VSP45A antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Vacuolar protein sorting-associated protein 45 protein (101-400AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，VPS45 Antibody (CSB-PA882092LA01HU)，的标记方式是Non-conjugated。对于VPS45 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA882092LB01HU VPS45 Antibody, HRP conjugated ELISA
    FITC CSB-PA882092LC01HU VPS45 Antibody, FITC conjugated
    Biotin CSB-PA882092LD01HU VPS45 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network.
  • 基因功能参考文献：
    1. A homozygous VPS45 p.E238K mutation is associated with severe congenital neutropenia with neurological impairment. PMID: 26358756
    2. we identified a Thr224Asn mutation in the VPS45 gene in infants from consanguineous families who suffered from life-threatening neutropenia. PMID: 23599270
    3. Defective endosomal intracellular protein trafficking due to biallelic mutations in VPS45 underlies a new immunodeficiency syndrome involving impaired neutrophil function. PMID: 23738510
    4. Data implicate hVps45 and Rabenosyn-5 in post early endosome transport, and suggest that their interaction serves as a nexus to promote bidirectional transport along the endosome-to-recycling compartment and endosome-to-Golgi axes. PMID: 19931244
  • 相关疾病：
    Neutropenia, severe congenital 5, autosomal recessive (SCN5)
  • 亚细胞定位：
    Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
  • 蛋白家族：
    STXBP/unc-18/SEC1 family
  • 组织特异性：
    Ubiquitous. Expression was highest in testis, heart and brain, intermediate in kidney, spleen, prostate, ovary, small intestine and thymus and low in lung, skeletal muscle, placenta, colon, pancreas, peripheral blood leukocytes and liver.
  • 数据库链接：

    HGNC: 14579

    OMIM: 610035

    KEGG: hsa:11311

    STRING: 9606.ENSP00000358126

    UniGene: Hs.443750