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VTI1A Antibody

  • 货号：
    CSB-PA007322
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q96AJ9
  • 基因名：
    VTI1A
  • 别名：
    MMDS3 antibody; MVti1 antibody; SNARE Vti1a beta protein antibody; Vesicle transport through interaction with t-SNAREs homolog 1A antibody; Vesicle transport through interaction with tSNAREs homolog 1A (yeast) antibody; Vesicle transport v-SNARE protein Vti1-like 2 antibody; Vti1 rp2 antibody; Vti1-rp2 antibody; Vti1a antibody; VTI1A vesicle transport through interaction with t-SNAREs 1A antibody; VTI1A_HUMAN antibody; VTI1RP2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human v-SNARE Vti1a.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence.
  • 基因功能参考文献：
    1. Novel variants of VTI1A-TCF7L2 fusion transcripts, including a novel fusion partner gene, RP11-57H14.3, was identified and demonstrated detectable levels in a large fraction of colorectal cancer samples.[RP11-57H14.3] PMID: 24608966
    2. our results indicate that genetic variants in VTI1A may modify individual susceptibility to non-GBM of glioma in the Han Chinese population and support the role of the VTI1A genes in the occurrence of glioma. PMID: 28320150
    3. The AA genotype of VTI1A (rs7086803) polymorphism had an increased risk of developing NSCLC compared with the GG genotype. Smoking lung cancer patients with the AA genotype of VTI1A gene (rs7086803) had a poor survival rate. PMID: 25744365
    4. analysis of a new susceptibility locus for colorectal cancer in VTI1A [meta-analysis] PMID: 25105248
    5. Data indicate that depletion of VAMP4, syntaxin 6, syntaxin 16, and Vti1a disrupted the Golgi ribbon structure. PMID: 23677696
    6. We found a colorectal carcinoma cell line harboring the fusion gene to be dependent on VTI1A-TCF7L2 for anchorage-independent growth using RNA interference-mediated knockdown. PMID: 21892161
    7. The present results suggest that a SNARE complex containing VAMP7 and Vti1a defines a novel traffic pathway to the cell surface in both neuronal and non-neuronal cells. PMID: 19138172

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  • 亚细胞定位：
    Cytoplasmic vesicle. Golgi apparatus membrane; Single-pass type IV membrane protein.
  • 蛋白家族：
    VTI1 family
  • 数据库链接：

    HGNC: 17792

    OMIM: 614316

    KEGG: hsa:143187

    STRING: 9606.ENSP00000376792

    UniGene: Hs.194554