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  4. WBP11 Antibody

WBP11 Antibody

  • 中文名称：
    WBP11兔多克隆抗体
  • 货号：
    CSB-PA025975GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y2W2
  • 基因名：
    WBP11
  • 别名：
    DKFZp779M1063 antibody; MGC94547 antibody; Npw38 binding protein antibody; Npw38 binding protein NpwBP antibody; Npw38-binding protein antibody; NpwBP antibody; PPP1R165 antibody; Protein phosphatase 1 regulatory subunit 165 antibody; SH3 domain binding protein SNP70 antibody; SH3 domain-binding protein SNP70 antibody; SIPP1 antibody; SNP70 antibody; Splicing factor PQBP1 and PP1 interacting antibody; Splicing factor that interacts with PQBP 1 and PP1 antibody; Splicing factor that interacts with PQBP-1 and PP1 antibody; WBP 11 antibody; WBP-11 antibody; Wbp11 antibody; WBP11_HUMAN antibody; WW domain binding protein 11 antibody; WW domain-binding protein 11 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human WBP11
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity.
  • 基因功能参考文献：
    1. The WW domain belonging to polyglutamine tract-binding protein 1 (PQBP1) is of particular interest due to its direct involvement in several X chromosome-linked intellectual disabilities, including Golabi-Ito-Hall (GIH) syndrome, where a single point mutation (Y65C) correlates with the development of the disease. The mutant cannot bind to its natural ligand WBP11, which regulates mRNA processing PMID: 27456546
    2. SIPP1 is a positive regulator of pre-mRNA splicing that is regulated by nucleocytoplasmic shuttling PMID: 16162498
  • 亚细胞定位：
    Nucleus. Cytoplasm. Note=Predominantly located in the nucleus with granular heterogeneous distribution. Excluded from nucleoli in interphase cells, distributed throughout cytoplasm in dividing cells. Colocalized with SC35 and U2B in the nucleus. In the cytoplasm, associates with the intermediate filament protein vimentin.
  • 组织特异性：
    Ubiquitous. Highly expressed in the heart, pancreas, kidney skeletal muscle, placenta and brain (at protein level). Weakly expressed in liver and lung.
  • 数据库链接：

    HGNC: 16461

    KEGG: hsa:51729

    STRING: 9606.ENSP00000261167

    UniGene: Hs.655138