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WDFY3 Antibody

  • 货号：
    CSB-PA809030LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA809030LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA809030LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA809030LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) WDFY3 Polyclonal antibody
  • Uniprot No.：
    Q8IZQ1
  • 基因名：
    WDFY3
  • 别名：
    WDFY3 antibody; KIAA0993 antibody; WD repeat and FYVE domain-containing protein 3 antibody; Autophagy-linked FYVE protein antibody; Alfy antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human WD repeat and FYVE domain-containing protein 3 protein (1-100AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，WDFY3 Antibody (CSB-PA809030LA01HU)，的标记方式是Non-conjugated。对于WDFY3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA809030LB01HU WDFY3 Antibody, HRP conjugated ELISA
    FITC CSB-PA809030LC01HU WDFY3 Antibody, FITC conjugated
    Biotin CSB-PA809030LD01HU WDFY3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3. Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus. Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1. Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development. May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway. After cytokinetic abscission, involved in midbody remnant degradation. In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P).
  • 基因功能参考文献：
    1. we demonstrate that normally ALFY attenuates the canonical Wnt signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 and not of Dvl1 or Dvl2. PMID: 27008544
    2. ALFY binds selectively to LC3C and the GABARAPs through a LC3-interacting region in its WD40 domain. PMID: 24668264
    3. increasing Alfy-mediated protein degradation may be beneficial in some organs, but may be detrimental in others PMID: 21150266
    4. Data suggest that p62 and ALFY interact to organize misfolded, ubiquitinated proteins into protein bodies that become degraded by autophagy. PMID: 20168092
    5. The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. PMID: 20417604
    6. Alfy might target cytosolic protein aggregates for autophagic degradation. PMID: 15292400

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  • 相关疾病：
    Microcephaly 18, primary, autosomal dominant (MCPH18)
  • 亚细胞定位：
    Nucleus membrane. Cytoplasm, cytosol. Nucleus, PML body. Membrane; Peripheral membrane protein; Cytoplasmic side. Perikaryon. Cell projection, axon.
  • 组织特异性：
    Expressed in osteoclast and their mononuclear precursors (at protein level).
  • 数据库链接：

    HGNC: 20751

    OMIM: 617485

    KEGG: hsa:23001

    STRING: 9606.ENSP00000295888

    UniGene: Hs.480116