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WDR19 Antibody

  • 货号：
    CSB-PA836733LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA836733LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA836733LA01HU at dilution of 1:100
    • Immunofluorescent analysis of A549 cells using CSB-PA836733LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) WDR19 Polyclonal antibody
  • Uniprot No.：
    Q8NEZ3
  • 基因名：
    WDR19
  • 别名：
    DYF 2 antibody; DYF2 antibody; FLJ23127 antibody; IFT144 antibody; Intraflagellar transport 144 homolog antibody; KIAA1638 antibody; ORF26 antibody; Oseg6 antibody; PWDMP antibody; WD repeat containing protein 19 antibody; WD repeat domain 19 antibody; WD repeat membrane protein PWDMP antibody; WD repeat-containing protein 19 antibody; Wdr19 antibody; WDR19_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human WD repeat-containing protein 19 protein (45-226AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，WDR19 Antibody (CSB-PA836733LA01HU)，的标记方式是Non-conjugated。对于WDR19 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA836733LB01HU WDR19 Antibody, HRP conjugated ELISA
    FITC CSB-PA836733LC01HU WDR19 Antibody, FITC conjugated
    Biotin CSB-PA836733LD01HU WDR19 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    As component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in cilia function and/or assembly. Essential for functional IFT-A assembly and ciliary entry of GPCRs. Associates with the BBSome complex to mediate ciliary transport.
  • 基因功能参考文献：
    1. Case Reports: that WDR19 mutations can cause dysplastic kidney in addition to nephronophthisis in infants with Sensenbrenner syndrome. PMID: 28621010
    2. Nephronophthisis 13 (Autosomal Recessive Polycystic Kidney Disease) is associated with mutations in the WDR19 gene.Caroli disease is a major extra-renal phenotype associated with mutations in WDR19 in the Korean population. PMID: 25726036
    3. WDR19 mutations can cause a broad spectrum of ciliopathies that extends to Jeune and Sensenbrenner syndromes, RP and renal NPHP-like phenotypes PMID: 24504730
    4. Mutations in WDR19 gene is associated with Caroli disease. PMID: 23559409
    5. WDR19: an ancient, retrograde, intraflagellar ciliary protein is mutated in autosomal recessive retinitis pigmentosa and in Senior-Loken syndrome. PMID: 23683095
    6. Ciliopathies with skeletal anomalies and renal insufficiency due to mutations in the IFT-A gene WDR19 PMID: 22019273
    7. Expressed in normal and neoplastic prostate epithelium and is regulated by androgenic hormones. PMID: 12906858
    8. Overexpression of WDR19 is associated with prostate cancer PMID: 18316561

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  • 相关疾病：
    Cranioectodermal dysplasia 4 (CED4); Short-rib thoracic dysplasia 5 with or without polydactyly (SRTD5); Nephronophthisis 13 (NPHP13); Senior-Loken syndrome 8 (SLSN8)
  • 亚细胞定位：
    Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium, photoreceptor outer segment.
  • 组织特异性：
    Some isoforms are tissue-specific. Highly expressed in the prostate. Lower expression in the cerebellum, pituitary gland, fetal lung, and pancreas. In normal prostate, expressed in both basal and luminal epithelial cells. No expression detected in fibromu
  • 数据库链接：

    HGNC: 18340

    OMIM: 608151

    KEGG: hsa:57728

    STRING: 9606.ENSP00000382717

    UniGene: Hs.438482