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WSS1 Antibody

  • 货号：
    CSB-PA334485LA01SVG
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Saccharomyces cerevisiae WSS1 Polyclonal antibody
  • Uniprot No.：
    P38838
  • 基因名：
    WSS1
  • 别名：
    WSS1 antibody; YHR134WDNA-dependent metalloprotease WSS1 antibody; EC 3.4.24.- antibody; DNA damage response protein WSS1 antibody; SUMO-dependent isopeptidase WSS1 antibody; Weak suppressor of SMT3 protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Saccharomyces cerevisiae
  • 免疫原：
    Recombinant Saccharomyces cerevisiae DNA-dependent metalloprotease WSS1 protein (1-269AA)
  • 免疫原种属：
    Saccharomyces cerevisiae
  • 标记方式：
    Non-conjugated

    本页面中的产品，WSS1 Antibody (CSB-PA334485LA01SVG)，的标记方式是Non-conjugated。对于WSS1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA334485LB01SVG WSS1 Antibody, HRP conjugated ELISA
    FITC CSB-PA334485LC01SVG WSS1 Antibody, FITC conjugated
    Biotin CSB-PA334485LD01SVG WSS1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Metalloendopeptidase that acts selectively on DNA-binding proteins. DNA is needed to bring the protease and substrates together to enable proteolysis. Involved in the repair of toxic DNA-protein cross-links (DPCs) such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesions or DPCs induced by reactive compounds such as formaldehyde. Involved in DNA damage response and processing of stalled or collapsed replication forks by removing the covalently trapped TOP1 from chromatin. DPC proteolysis enables the repair of the lesions via downstream DNA repair pathways. May be recruited to DPCs via the SUMOylation of substrate proteins at damaged DNA sites.
  • 基因功能参考文献：
    1. e show that SPRTN is a DNA-dependent mammalian protease required for resolving cytotoxic DNA-protein crosslinks (DPCs)- a function that had only been attributed to the metalloprotease Wss1 in budding yeast. We provide genetic evidence that SPRTN and Wss1 function distinctly in vivo to resolve DPCs PMID: 27852435
    2. Data suggest that Wss1 contributes to survival of DNA-protein crosslink (DPC)-harboring cells by acting on DPCs proteolytically. Wss1 enables replication of DPC-containing DNA and thus promotes genome integrity. PMID: 24998930
    3. Involement of WSS1 in the DNA damage response. PMID: 15598824
    4. In dividing cells, Wss1 is exclusively present in the mother cell. PMID: 18336552
  • 亚细胞定位：
    Nucleus. Note=Present in a single sharp spot near the nuclear membrane, distinct from the spindle pole bodies and nucleolus. In dividing cells, the spot is exclusively present in the mother cell.
  • 蛋白家族：
    Peptidase M3 family, WSS1-like metalloprotease (WLM) subfamily
  • 数据库链接：

    KEGG: sce:YHR134W

    STRING: 4932.YHR134W